Idiopathic inflammatory myopathy associated with malignancy: a retrospective cohort of 151 Korean patients with dermatomyositis and polymyositis - PubMed (original) (raw)
. 2011 Nov;38(11):2432-5.
doi: 10.3899/jrheum.110320. Epub 2011 Aug 15.
Affiliations
- PMID: 21844145
- DOI: 10.3899/jrheum.110320
Idiopathic inflammatory myopathy associated with malignancy: a retrospective cohort of 151 Korean patients with dermatomyositis and polymyositis
Min Wook So et al. J Rheumatol. 2011 Nov.
Abstract
Objective: To define the standardized incidence ratio (SIR) of malignancy and factors associated with malignancies in Korean patients with dermatomyositis (DM) and polymyositis (PM).
Methods: The demographic, clinical, and laboratory features of 151 patients diagnosed with DM/PM were compared in patients with and without malignancies.
Results: Malignancies were found in 23 of 98 patients with DM (23.5%) and in 2 of 53 with PM (3.8%). Lung cancer (8 patients) was the most common malignancy. Compared with the period-specific, sex-matched, and age-matched Korean population, the SIR for malignancy in patients with DM was 14.2 (95% CI 9.0-21.3). Univariate analysis showed that factors associated with malignancy included older age (p < 0.001), DM (p = 0.002), dysphagia (p < 0.001), the absence of interstitial lung disease (ILD; p = 0.001), and lower elevations in aspartate aminotransferase (p = 0.005) and lactate dehydrogenase concentrations (p < 0.001). Multivariate analysis showed that factors independently associated with malignancy included older age (per 10 years, OR 2.3, 95% CI 1.6-3.5, p < 0.001), DM (OR 5.9, 95% CI 1.3-26.2, p = 0.020), dysphagia (OR 2.6, 95% CI 1.2-6.6, p = 0.042), and the absence of ILD (OR 0.1, 95% CI 0.01-0.9, p = 0.040).
Conclusion: DM was associated with a greater risk of concomitant malignancies, especially lung cancer, than PM. Independent factors associated with malignancies in patients with DM/PM were older age, the presence of dysphagia, and the absence of ILD.
Similar articles
- Predictive factors and unfavourable prognostic factors of interstitial lung disease in patients with polymyositis or dermatomyositis: a retrospective study.
Ji SY, Zeng FQ, Guo Q, Tan GZ, Tang HF, Luo YJ, Tang ZQ, Han YF. Ji SY, et al. Chin Med J (Engl). 2010 Mar 5;123(5):517-22. Chin Med J (Engl). 2010. PMID: 20367973 - [The predictive factors and unfavourable prognostic factors of interstitial lung disease in patients with polymyositis/dermatomyositis].
Wang PZ, Guan JL, Han XH. Wang PZ, et al. Zhonghua Jie He He Hu Xi Za Zhi. 2008 Jun;31(6):417-20. Zhonghua Jie He He Hu Xi Za Zhi. 2008. PMID: 19031800 Chinese. - Incidence and predictive factors for malignancies in 136 Japanese patients with dermatomyositis, polymyositis and clinically amyopathic dermatomyositis.
Azuma K, Yamada H, Ohkubo M, Yamasaki Y, Yamasaki M, Mizushima M, Ozaki S. Azuma K, et al. Mod Rheumatol. 2011 Apr;21(2):178-83. doi: 10.1007/s10165-010-0362-y. Epub 2010 Oct 5. Mod Rheumatol. 2011. PMID: 20922453 - Hematological malignancy associated with polymyositis and dermatomyositis.
Marie I, Guillevin L, Menard JF, Hatron PY, Cherin P, Amoura Z, Cacoub P, Bachelez H, Buzyn A, Le Roux G, Ziza JM, Brice P, Munck JN, Sarrot-Reynauld F, Piette JC, Larroche C. Marie I, et al. Autoimmun Rev. 2012 Jul;11(9):615-20. doi: 10.1016/j.autrev.2011.10.024. Epub 2011 Oct 30. Autoimmun Rev. 2012. PMID: 22079677 Review. - Dermatomyositis and ovarian cancer: a report of 7 cases and literature review.
Cherin P, Piette JC, Herson S, Bletry O, Wechsler B, Frances C, Godeau P. Cherin P, et al. J Rheumatol. 1993 Nov;20(11):1897-9. J Rheumatol. 1993. PMID: 8308775 Review.
Cited by
- Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis.
Allenzara A, Sadeghi N, Alvarez C, Maczuga S, Helm M, Olsen N, Nelson A, Foulke G. Allenzara A, et al. Semin Arthritis Rheum. 2024 Feb;64:152283. doi: 10.1016/j.semarthrit.2023.152283. Epub 2023 Nov 4. Semin Arthritis Rheum. 2024. PMID: 37984228 - Successful management of interstitial lung disease in dermatomyositis complicated by malignancy: a case-based review.
Katakura T, Shirai T, Sato H, Ishii T, Fujii H. Katakura T, et al. Rheumatol Int. 2024 Sep;44(9):1781-1788. doi: 10.1007/s00296-023-05442-y. Epub 2023 Sep 8. Rheumatol Int. 2024. PMID: 37682289 - Interstitial lung disease is associated with an increased risk of lung cancer in systemic sclerosis: Longitudinal data from the Canadian Scleroderma Research Group.
Sakr L, Hudson M, Wang M, Younanian E, Baron M, Bernatsky S; Canadian Scleroderma Research Group. Sakr L, et al. J Scleroderma Relat Disord. 2018 Oct;3(3):221-227. doi: 10.1177/2397198318766825. Epub 2018 Apr 10. J Scleroderma Relat Disord. 2018. PMID: 35382016 Free PMC article. - Update on Malignancy in Myositis-Well-Established Association with Unmet Needs.
Opinc AH, Makowska JS. Opinc AH, et al. Biomolecules. 2022 Jan 11;12(1):111. doi: 10.3390/biom12010111. Biomolecules. 2022. PMID: 35053259 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical