Rab8 GTPase as a regulator of cell shape - PubMed (original) (raw)
Review
. 2011 Oct;68(10):527-39.
doi: 10.1002/cm.20529. Epub 2011 Sep 9.
Affiliations
- PMID: 21850707
- DOI: 10.1002/cm.20529
Review
Rab8 GTPase as a regulator of cell shape
Johan Peränen. Cytoskeleton (Hoboken). 2011 Oct.
Abstract
Endogenous Rab8 is found in dynamic cell structures like filopodia, lamellipodia, protrusions, ruffles, and primary cilia. Activation of Rab8 is linked to the formation of these actin containing structures, whereas inhibition of Rab8 affects negatively their appearance. The activity of Rab8 is controlled by specific guanine nucleotide exchange factors and GTPase activating proteins. Rab8 regulates a membrane recycling pathway that is linked to Arf6, EHD1, Myo5, and Rab11. A hypothesis is presented on the role of Rab8 in the formation of new cell surface domains. The review focuses on the function of Rab8 in cell migration, epithelial polarization, neuron differentiation, and ciliogenesis.
Copyright © 2011 Wiley-Liss, Inc.
Similar articles
- Characterization of the Rab8-specific membrane traffic route linked to protrusion formation.
Hattula K, Furuhjelm J, Tikkanen J, Tanhuanpää K, Laakkonen P, Peränen J. Hattula K, et al. J Cell Sci. 2006 Dec 1;119(Pt 23):4866-77. doi: 10.1242/jcs.03275. Epub 2006 Nov 14. J Cell Sci. 2006. PMID: 17105768 - CLEM Characterization of Rab8 and Associated Membrane Trafficking Regulators at Primary Cilium Structures.
Lu Q, Westlake CJ. Lu Q, et al. Methods Mol Biol. 2021;2293:91-103. doi: 10.1007/978-1-0716-1346-7_7. Methods Mol Biol. 2021. PMID: 34453712 Free PMC article. - A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.
Feng S, Knödler A, Ren J, Zhang J, Zhang X, Hong Y, Huang S, Peränen J, Guo W. Feng S, et al. J Biol Chem. 2012 May 4;287(19):15602-9. doi: 10.1074/jbc.M111.333245. Epub 2012 Mar 19. J Biol Chem. 2012. PMID: 22433857 Free PMC article. - Rab-mediated trafficking role in neurite formation.
Villarroel-Campos D, Gastaldi L, Conde C, Caceres A, Gonzalez-Billault C. Villarroel-Campos D, et al. J Neurochem. 2014 Apr;129(2):240-8. doi: 10.1111/jnc.12676. Epub 2014 Mar 10. J Neurochem. 2014. PMID: 24517494 Review. - Rab35: GEFs, GAPs and effectors.
Chaineau M, Ioannou MS, McPherson PS. Chaineau M, et al. Traffic. 2013 Nov;14(11):1109-17. doi: 10.1111/tra.12096. Epub 2013 Aug 21. Traffic. 2013. PMID: 23905989 Review.
Cited by
- Roles of lipid droplets and related proteins in metabolic diseases.
Zhang Z, Yu Z, Liang D, Song K, Kong X, He M, Liao X, Huang Z, Kang A, Bai R, Ren Y. Zhang Z, et al. Lipids Health Dis. 2024 Jul 19;23(1):218. doi: 10.1186/s12944-024-02212-y. Lipids Health Dis. 2024. PMID: 39030618 Free PMC article. Review. - Rab8a/SNARE complex activation promotes vesicle anchoring and transport in spinal astrocytes to drive neuropathic pain.
Xiao Y, Wang G, He G, Qin W, Shi Y. Xiao Y, et al. Biomol Biomed. 2024 Sep 6;24(5):1290-1300. doi: 10.17305/bb.2024.10441. Biomol Biomed. 2024. PMID: 38691557 Free PMC article. - An Update on the Interplay between LRRK2, Rab GTPases and Parkinson's Disease.
Komori T, Kuwahara T. Komori T, et al. Biomolecules. 2023 Nov 13;13(11):1645. doi: 10.3390/biom13111645. Biomolecules. 2023. PMID: 38002327 Free PMC article. Review. - Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W. Wu T, et al. Oncogene. 2023 Sep;42(38):2801-2815. doi: 10.1038/s41388-023-02807-2. Epub 2023 Aug 15. Oncogene. 2023. PMID: 37582861 - Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases.
Takahashi T, Shirai J, Matsuda M, Nakanaga S, Matsushita S, Wakita K, Hayashishita M, Suzuki R, Noguchi A, Yokota N, Kawahara H. Takahashi T, et al. iScience. 2023 Apr 10;26(5):106652. doi: 10.1016/j.isci.2023.106652. eCollection 2023 May 19. iScience. 2023. PMID: 37182096 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous