Associated symptoms of kawasaki disease - PubMed (original) (raw)
Associated symptoms of kawasaki disease
Sang Hyun Yun et al. Korean Circ J. 2011 Jul.
Abstract
Background and objectives: In addition to diagnostic criteria, a broad range of nonspecific clinical features can be found in patients with Kawasaki disease. This lack of specificity may cause confusion with other febrile illnesses and delay the diagnosis of Kawasaki disease. The purpose of this study is to describe common associated symptoms and their clinical significances in children affected with Kawasaki disease.
Subjects and methods: As a retrospective study, we reviewed the medical records of 121 children who were treated for Kawasaki disease at Presbyterian medical center from January 2005 to June 2010. All clinical symptoms, laboratory data and echocardiographic findings in patients with KD were collected and analyzed.
Results: We found that there are 9 associated symptoms, namely cough, rhinorrhea, sputum, abdominal pain, vomiting, diarrhea, arthralgia, headache and seizure, which occur in patients with Kawasaki disease. Among the study group, there were only 32 children with no associated symptoms (26.4%). Patients with abdominal pain and headache had an older mean age than those without such symptoms. The incidence of seizure was significantly higher in incomplete Kawasaki disease patients compared with those with complete Kawasaki disease. Vomiting was highly associated with IVIG non-responder group.
Conclusion: To decrease the incidence of serious coronary complications due to delayed diagnosis, physicians need to be aware of the manifestations of Kawasaki disease and the possibility of associated symptoms, which, being unspecific, may otherwise not raise any red flags.
Keywords: Mucocutaneous lymph node syndrome; Signs and symptoms.
Conflict of interest statement
The authors have no financial conflicts of interest.
Similar articles
- Associated symptoms in the ten days before diagnosis of Kawasaki disease.
Baker AL, Lu M, Minich LL, Atz AM, Klein GL, Korsin R, Lambert L, Li JS, Mason W, Radojewski E, Vetter VL, Newburger JW; Pediatric Heart Network Investigators. Baker AL, et al. J Pediatr. 2009 Apr;154(4):592-595.e2. doi: 10.1016/j.jpeds.2008.10.006. Epub 2008 Nov 28. J Pediatr. 2009. PMID: 19038400 Free PMC article. - Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease.
Gamez-Gonzalez LB, Moribe-Quintero I, Cisneros-Castolo M, Varela-Ortiz J, Muñoz-Ramírez M, Garrido-García M, Yamazaki-Nakashimada M. Gamez-Gonzalez LB, et al. Pediatr Int. 2018 Sep;60(9):781-790. doi: 10.1111/ped.13614. Pediatr Int. 2018. PMID: 29888440 - Efficacy and safety of intravenous immunoglobulin plus prednisolone therapy in patients with Kawasaki disease (Post RAISE): a multicentre, prospective cohort study.
Miyata K, Kaneko T, Morikawa Y, Sakakibara H, Matsushima T, Misawa M, Takahashi T, Nakazawa M, Tamame T, Tsuchihashi T, Yamashita Y, Obonai T, Chiga M, Hori N, Komiyama O, Yamagishi H, Miura M; Post RAISE group. Miyata K, et al. Lancet Child Adolesc Health. 2018 Dec;2(12):855-862. doi: 10.1016/S2352-4642(18)30293-1. Epub 2018 Oct 16. Lancet Child Adolesc Health. 2018. PMID: 30337183 - Gastrointestinal hemorrhage before anticoagulant therapy in Kawasaki disease: a case report.
Hu C, Yu Y. Hu C, et al. BMC Pediatr. 2020 Jan 27;20(1):32. doi: 10.1186/s12887-020-1916-6. BMC Pediatr. 2020. PMID: 31987031 Free PMC article. Review. - Intestinal Involvement in Kawasaki Disease.
Colomba C, La Placa S, Saporito L, Corsello G, Ciccia F, Medaglia A, Romanin B, Serra N, Di Carlo P, Cascio A. Colomba C, et al. J Pediatr. 2018 Nov;202:186-193. doi: 10.1016/j.jpeds.2018.06.034. Epub 2018 Jul 17. J Pediatr. 2018. PMID: 30029859 Review.
Cited by
- Acalculous Cholecystitis From Kawasaki Disease in a Three-Month-Old Girl: A Rare Sign at an Uncommon Age.
Sriphongphankul H, Jarutach J, Chaisujyakorn T, Kritsaneepaiboon S, Janjindamai P. Sriphongphankul H, et al. Cureus. 2024 Jul 19;16(7):e64929. doi: 10.7759/cureus.64929. eCollection 2024 Jul. Cureus. 2024. PMID: 39156331 Free PMC article. - Systemic vasculitis and headache.
Younger DS. Younger DS. Curr Opin Neurol. 2023 Dec 1;36(6):631-646. doi: 10.1097/WCO.0000000000001223. Epub 2023 Oct 12. Curr Opin Neurol. 2023. PMID: 37865837 Free PMC article. Review. - Clinical-laboratory profile of children and adolescents with multisystem inflammatory syndrome temporarily associated with COVID-19 in Goiás, Brazil.
da Costa MA, de Almeida RPA, Pondé RAA. da Costa MA, et al. Arch Virol. 2023 Apr 17;168(5):142. doi: 10.1007/s00705-023-05748-z. Arch Virol. 2023. PMID: 37067652 Free PMC article. - Neurological manifestations of Kawasaki disease and multisystem inflammatory syndrome in children associated with COVID-19: A comparison of two different clinical entities.
Mauro A, Di Mari C, Casini F, Giani T, Sandini M, Biondi L, Calcaterra V, Zuccotti GV, Bernardo L. Mauro A, et al. Front Pediatr. 2023 Jan 5;10:1088773. doi: 10.3389/fped.2022.1088773. eCollection 2022. Front Pediatr. 2023. PMID: 36683824 Free PMC article. Review. - Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features.
Lee W, Cheah CS, Suhaini SA, Azidin AH, Khoo MS, Ismail NAS, Ali A. Lee W, et al. Medicina (Kaunas). 2022 May 30;58(6):734. doi: 10.3390/medicina58060734. Medicina (Kaunas). 2022. PMID: 35743997 Free PMC article. Review.
References
- Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi. 1967;16:178–222. - PubMed
- Burns JC, Glodé MP. Kawasaki syndrome. Lancet. 2004;364:533–544. - PubMed
- Kato H, Sugimura T, Akagi T, et al. Long-term consequences of Kawasaki disease: a 10- to 21-year follow-up study of 594 patients. Circulation. 1996;94:1379–1385. - PubMed
- Dajani AS, Taubert KA, Gerber MA, et al. Diagnosis and therapy of Kawasaki disease in children. Circulation. 1993;87:1776–1780. - PubMed
- Lee SY, Gwon HC, Park SW, et al. Acute myocardial infarction in young patient probably due to Kawasaki disease. Korean Circ J. 2001;31:119–124.
LinkOut - more resources
Full Text Sources
Research Materials