A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project - PubMed (original) (raw)
Review
. 2012 Jun;26(4):294-304.
doi: 10.1177/0269216311418709. Epub 2011 Aug 24.
Affiliations
- PMID: 21865295
- DOI: 10.1177/0269216311418709
Review
A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project
Anke Ries et al. Palliat Med. 2012 Jun.
Abstract
Background: The European Palliative Care Research Collaboration is developing clinical guidelines on cachexia in patients with advanced cancer. A systematic review on the use of fish oil/omega-3-fatty acids (n-3-FA)/eicosapentaenoic acids (EPA) in advanced cancer patients suffering from cancer cachexia was performed as part of the guideline development.
Methods: The systematic literature search in Medline on the use of fish oil/n-3-FA/EPA identified 244 papers, with 38 publications included in the final evaluation. Some smaller trials, often unrandomized and without a control group, reported a good effect of n-3-FA in patients with advanced cancer and cachexia. However, the results of the larger randomized controlled trials could not support the positive results, as they mostly did not find a significant effect.
Results: Adverse effects such as abdominal discomfort, fish belching, fish aftertaste, nausea and diarrhoea were reported with a low incidence. No serious adverse effects were documented, but adverse effects often had an impact on quality of life. This often limited dose escalations or even led to discontinuation of n-3-FA.
Conclusion: There is not enough evidence to support a net benefit of n-3-FA in cachexia in advanced cancer. On the other hand, adverse effects were infrequent, with no severe adverse effects. The results from the review led to a weak negative GRADE recommendation.
Similar articles
- Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer.
Cerchietti LC, Navigante AH, Castro MA. Cerchietti LC, et al. Nutr Cancer. 2007;59(1):14-20. doi: 10.1080/01635580701365068. Nutr Cancer. 2007. PMID: 17927497 Clinical Trial. - N-3 fatty acids, cancer and cachexia: a systematic review of the literature.
Colomer R, Moreno-Nogueira JM, García-Luna PP, García-Peris P, García-de-Lorenzo A, Zarazaga A, Quecedo L, del Llano J, Usán L, Casimiro C. Colomer R, et al. Br J Nutr. 2007 May;97(5):823-31. doi: 10.1017/S000711450765795X. Br J Nutr. 2007. PMID: 17408522 Review. - Dietary supplementation with n-3-fatty acids in patients with pancreatic cancer and cachexia: marine phospholipids versus fish oil - a randomized controlled double-blind trial.
Werner K, Küllenberg de Gaudry D, Taylor LA, Keck T, Unger C, Hopt UT, Massing U. Werner K, et al. Lipids Health Dis. 2017 Jun 2;16(1):104. doi: 10.1186/s12944-017-0495-5. Lipids Health Dis. 2017. PMID: 28578704 Free PMC article. Clinical Trial. - A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project.
Mochamat, Cuhls H, Marinova M, Kaasa S, Stieber C, Conrad R, Radbruch L, Mücke M. Mochamat, et al. J Cachexia Sarcopenia Muscle. 2017 Feb;8(1):25-39. doi: 10.1002/jcsm.12127. Epub 2016 Jul 20. J Cachexia Sarcopenia Muscle. 2017. PMID: 27897391 Free PMC article. Review. - Fish oil supplementation in the treatment of cachexia in pancreatic cancer patients.
Brown TT, Zelnik DL, Dobs AS. Brown TT, et al. Int J Gastrointest Cancer. 2003;34(2-3):143-50. doi: 10.1385/IJGC:34:2-3:143. Int J Gastrointest Cancer. 2003. PMID: 15361649 Review.
Cited by
- Cancer Cachexia: Definition, Staging, and Emerging Treatments.
Ni J, Zhang L. Ni J, et al. Cancer Manag Res. 2020 Jul 9;12:5597-5605. doi: 10.2147/CMAR.S261585. eCollection 2020. Cancer Manag Res. 2020. PMID: 32753972 Free PMC article. Review. - Therapeutic strategies against cancer cachexia.
Argilés JM, López-Soriano FJ, Stemmler B, Busquets S. Argilés JM, et al. Eur J Transl Myol. 2019 Feb 27;29(1):7960. doi: 10.4081/ejtm.2019.7960. eCollection 2019 Jan 11. Eur J Transl Myol. 2019. PMID: 31019661 Free PMC article. - Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications.
Freitas RDS, Campos MM. Freitas RDS, et al. Nutrients. 2019 Apr 26;11(5):945. doi: 10.3390/nu11050945. Nutrients. 2019. PMID: 31035457 Free PMC article. Review. - The muscle mass, omega-3, diet, exercise and lifestyle (MODEL) study - a randomised controlled trial for women who have completed breast cancer treatment.
McDonald C, Bauer J, Capra S, Coll J. McDonald C, et al. BMC Cancer. 2014 Apr 16;14:264. doi: 10.1186/1471-2407-14-264. BMC Cancer. 2014. PMID: 24739260 Free PMC article. Clinical Trial. - Impact of Early Incorporation of Nutrition Interventions as a Component of Cancer Therapy in Adults: A Review.
Richards J, Arensberg MB, Thomas S, Kerr KW, Hegazi R, Bastasch M. Richards J, et al. Nutrients. 2020 Nov 5;12(11):3403. doi: 10.3390/nu12113403. Nutrients. 2020. PMID: 33167544 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials