Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images - PubMed (original) (raw)
Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images
Enock Jonathan et al. J Biophotonics. 2011 Sep.
Abstract
Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans-cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down-to mean diameters of about 24 μm. Our technique has potential applications in cardiovascular-related parameter measurements such as volumetric flow as well as in assessing vascular density of normal and diseased tissue.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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