Vitamin E decreased the activity of acetylcholinesterase and level of lipid peroxidation in brain of rats exposed to aged and diluted sidestream smoke - PubMed (original) (raw)
. 2011 Dec;13(12):1210-9.
doi: 10.1093/ntr/ntr154. Epub 2011 Sep 6.
Affiliations
- PMID: 21896885
- DOI: 10.1093/ntr/ntr154
Vitamin E decreased the activity of acetylcholinesterase and level of lipid peroxidation in brain of rats exposed to aged and diluted sidestream smoke
Gustavo Roberto Thomé et al. Nicotine Tob Res. 2011 Dec.
Abstract
Introduction: The biological systems of both smoker and passive smoking suffer changes caused by toxic compounds from cigarette smoke such as inflammation, lipid peroxidation, and deficiency of vitamin E. The aim of the present study was to evaluate the effect of vitamin E on acetylcholinesterase (AChE) activity and the lipid peroxidation level in the brain of rats in the model of exposure to aged and diluted sidestream smoke (ADSS).
Methods: Adult male Wistar rats (200-300 g) were exposed to ADSS for 4 weeks and treated with vitamin E (50 mg/kg/day) loaded by gavage. In the first, second, third, and fourth weeks, animals were concomitantly exposed to the smoke of 1, 2, 3, and 4 cigarettes/day, respectively. The duration of each exposure was 15 min, daily.
Results: For rats exposed to ADSS, the AChE activity and lipid peroxidation level increased in the striatum, cerebral cortex, and cerebellum. In contrast, the activity of AChE and the level of lipid peroxidation decreased in the smoke group treated with vitamin E.
Conclusions: The results suggest that the rats exposed to ADSS and treated with vitamin E significantly reduced the raised activity of AChE and level lipid peroxidation from the brain structures studied. The study, therefore, concludes that vitamin E could be considered as a therapeutic agent in this type of exposure.
Similar articles
- Selenium and vitamin E modulates cigarette smoke exposure-induced oxidative stress in blood of rats.
Cay M, Naziroğlu M, Köylü H. Cay M, et al. Biol Trace Elem Res. 2009 Oct;131(1):62-70. doi: 10.1007/s12011-009-8347-4. Epub 2009 Mar 5. Biol Trace Elem Res. 2009. PMID: 19263002 - 17-β estradiol in the acetylcholinesterase activity and lipid peroxidation in the brain and blood of ovariectomized adult and middle-aged rats.
Martins DB, Mazzanti CM, França RT, Pagnoncelli M, Costa MM, de Souza EM, Gonçalves J, Spanevello R, Schmatz R, da Costa P, Mazzanti A, Beckmann DV, Cecim Mda S, Schetinger MR, Lopes ST. Martins DB, et al. Life Sci. 2012 Feb 27;90(9-10):351-9. doi: 10.1016/j.lfs.2011.12.006. Epub 2011 Dec 28. Life Sci. 2012. PMID: 22227472 - Acetylcholinesterase activity and lipid peroxidation in the brain and spinal cord of rats infected with Trypanosoma evansi.
da Silva AS, Monteiro SG, Gonçalves JF, Spanevello R, Oliveira CB, Costa MM, Jaques JA, Morsch VM, Schetinger MR, Mazzanti CM, Lopes ST. da Silva AS, et al. Vet Parasitol. 2011 Feb 10;175(3-4):237-44. doi: 10.1016/j.vetpar.2010.10.021. Epub 2010 Oct 20. Vet Parasitol. 2011. PMID: 21055876 - Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions.
Kaizer RR, Corrêa MC, Spanevello RM, Morsch VM, Mazzanti CM, Gonçalves JF, Schetinger MR. Kaizer RR, et al. J Inorg Biochem. 2005 Sep;99(9):1865-70. doi: 10.1016/j.jinorgbio.2005.06.015. J Inorg Biochem. 2005. PMID: 16055195 - Lipid peroxidation, vitamin E, and cardiovascular disease.
Musial J, Domagala TB, Szczeklik A. Musial J, et al. J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:200-3. doi: 10.3177/jnsv.38.special_200. J Nutr Sci Vitaminol (Tokyo). 1992. PMID: 1297740 Review. No abstract available.
Cited by
- How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways.
Moylan S, Jacka FN, Pasco JA, Berk M. Moylan S, et al. Brain Behav. 2013 May;3(3):302-26. doi: 10.1002/brb3.137. Epub 2013 Mar 26. Brain Behav. 2013. PMID: 23785661 Free PMC article. - Alterations in acetylcholinesterase and butyrylcholinesterase activities in chronic obstructive pulmonary disease: relationships with oxidative and inflammatory markers.
Ben Anes A, Ben Nasr H, Garrouch A, Bennour S, Bchir S, Hachana M, Benzarti M, Tabka Z, Chahed K. Ben Anes A, et al. Mol Cell Biochem. 2018 Aug;445(1-2):1-11. doi: 10.1007/s11010-017-3246-z. Epub 2017 Dec 12. Mol Cell Biochem. 2018. PMID: 29234928 - So depression is an inflammatory disease, but where does the inflammation come from?
Berk M, Williams LJ, Jacka FN, O'Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M. Berk M, et al. BMC Med. 2013 Sep 12;11:200. doi: 10.1186/1741-7015-11-200. BMC Med. 2013. PMID: 24228900 Free PMC article. Review. - Oxidative stress in the brain of cigarette smoke-induced noxiousness: neuroprotective role of Sesbania grandiflora.
Ramesh T, Sureka C, Bhuvana S, Begum VH. Ramesh T, et al. Metab Brain Dis. 2015 Apr;30(2):573-82. doi: 10.1007/s11011-014-9614-4. Epub 2014 Sep 9. Metab Brain Dis. 2015. PMID: 25217401 - Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats.
Ho YS, Yang X, Yeung SC, Chiu K, Lau CF, Tsang AW, Mak JC, Chang RC. Ho YS, et al. PLoS One. 2012;7(5):e36752. doi: 10.1371/journal.pone.0036752. Epub 2012 May 11. PLoS One. 2012. PMID: 22606286 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous