Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules - PubMed (original) (raw)
Review
. 2011 Oct;28(11):1811-53.
doi: 10.1039/c1np00045d. Epub 2011 Sep 8.
Affiliations
- PMID: 21901218
- DOI: 10.1039/c1np00045d
Review
Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules
Richard W Gantt et al. Nat Prod Rep. 2011 Oct.
Abstract
Glyco (randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of analogs wherein the sole diversity element is a carbohydrate. This review covers the influence of glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to glyco(randomization/diversification) schemes, approaches to the synthesis of required substrates and specific examples of glycorandomized libraries utilizing both wild-type and engineered enzymes.
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