The role of adiponectin in human vascular physiology - PubMed (original) (raw)
Review
. 2012 Mar 8;155(2):188-93.
doi: 10.1016/j.ijcard.2011.07.047. Epub 2011 Sep 9.
Affiliations
- PMID: 21907426
- DOI: 10.1016/j.ijcard.2011.07.047
Review
The role of adiponectin in human vascular physiology
Aristeidis G Vaiopoulos et al. Int J Cardiol. 2012.
Abstract
Adiponectin (ApN) is an adipose tissue-derived hormone which is involved in a wide variety of physiological processes including energy metabolism, inflammation, and vascular physiology via actions on a broad spectrum of target organs including liver, skeletal muscle, and vascular endothelium. Besides possessing insulin sensitizing and anti-inflammatory properties ApN also exerts a pivotal role in vascular protection through activation of multiple intracellular signaling cascades. Enhancement of nitric oxide generation and attenuation of reactive oxygen species production in endothelial cells along with reduced vascular smooth muscle cell proliferation and migration constitute some of ApN's vasoprotective actions. Additionally, recent data indicate that ApN has direct myocardio-protective effects. Decreased plasma ApN levels are implicated in the pathogenesis of the metabolic syndrome and atherosclerosis and may serve as a diagnostic and prognostic biomarker as well as a rational pharmaco-therapeutic target to treat these disorders. This review article summarizes recent work on the cardiovascular actions of ApN.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Comment in
- Inflammatory and anti-inflammatory indicators as predictive biomarkers of metabolic syndrome.
Kawada T. Kawada T. Int J Cardiol. 2012 Mar 8;155(2):285-6; author reply 286-7. doi: 10.1016/j.ijcard.2011.10.112. Epub 2011 Nov 12. Int J Cardiol. 2012. PMID: 22078402 No abstract available. - Paradoxical effects of adiponectin level on plaque vulnerability and clinical outcomes after coronary revascularization.
Kajiya T, Er BH, Chan MY, Low AF, Tan HC, Tai BC, Lee CH. Kajiya T, et al. Int J Cardiol. 2013 Oct 12;168(5):4796-8. doi: 10.1016/j.ijcard.2013.07.043. Epub 2013 Jul 22. Int J Cardiol. 2013. PMID: 23886528 No abstract available.
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