Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets - PubMed (original) (raw)
Review
. 2011 Nov-Dec;33(6):608-17.
doi: 10.1016/j.ntt.2011.07.007. Epub 2011 Jul 31.
Affiliations
- PMID: 21907791
- DOI: 10.1016/j.ntt.2011.07.007
Review
Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets
E P Rico et al. Neurotoxicol Teratol. 2011 Nov-Dec.
Abstract
Recent advances in neurobiology have emphasized the study of brain structure and function and its association with numerous pathological and toxicological events. Neurotransmitters are substances that relay, amplify, and modulate electrical signals between neurons and other cells. Neurotransmitter signaling mediates rapid intercellular communication by interacting with cell surface receptors, activating second messenger systems and regulating the activity of ion channels. Changes in the functional balance of neurotransmitters have been implicated in the failure of central nervous system function. In addition, abnormalities in neurotransmitter production or functioning can be induced by several toxicological compounds, many of which are found in the environment. The zebrafish has been increasingly used as an animal model for biomedical research, primarily due to its genetic tractability and ease of maintenance. These features make this species a versatile tool for pre-clinical drug discovery and toxicological investigations. Here, we present a review regarding the role of different excitatory and inhibitory neurotransmitter systems in zebrafish, such as dopaminergic, serotoninergic, cholinergic, purinergic, histaminergic, nitrergic, glutamatergic, glycinergic, and GABAergic systems, and emphasizing their features as pharmacological and toxicological targets. The increase in the global knowledge of neurotransmitter systems in zebrafish and the elucidation of their pharmacological and toxicological aspects may lead to new strategies and appropriate research priorities to offer insights for biomedical and environmental research.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
- 5-HT receptor regulation of neurotransmitter release.
Fink KB, Göthert M. Fink KB, et al. Pharmacol Rev. 2007 Dec;59(4):360-417. doi: 10.1124/pr.107.07103. Pharmacol Rev. 2007. PMID: 18160701 Review. - The serotonergic system in fish.
Lillesaar C. Lillesaar C. J Chem Neuroanat. 2011 Jul;41(4):294-308. doi: 10.1016/j.jchemneu.2011.05.009. Epub 2011 May 23. J Chem Neuroanat. 2011. PMID: 21635948 Review. - [Selective stimulations and lesions of the rat brain nuclei as the models for research of the human sleep pathology mechanisms].
Šaponjić J. Šaponjić J. Glas Srp Akad Nauka Med. 2011;(51):85-97. Glas Srp Akad Nauka Med. 2011. PMID: 22165729 Review. Serbian. - [Ontogenesis of the neurotransmitter systems].
Flores-Cruz GM, Escobar A. Flores-Cruz GM, et al. Rev Neurol. 2012 Jan 1;54(1):41-8. Rev Neurol. 2012. PMID: 22187211 Review. Spanish. - Zebrafish (Danio rerio) as a model organism for investigating endocrine disruption.
Segner H. Segner H. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Mar;149(2):187-95. doi: 10.1016/j.cbpc.2008.10.099. Epub 2008 Oct 14. Comp Biochem Physiol C Toxicol Pharmacol. 2009. PMID: 18955160
Cited by
- Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders.
Yin JH, Horzmann KA. Yin JH, et al. Biomedicines. 2024 Jul 13;12(7):1559. doi: 10.3390/biomedicines12071559. Biomedicines. 2024. PMID: 39062132 Free PMC article. Review. - How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity.
Collins ES, Hessel EVS, Hughes S. Collins ES, et al. Neurotoxicology. 2024 May;102:48-57. doi: 10.1016/j.neuro.2024.03.005. Epub 2024 Mar 28. Neurotoxicology. 2024. PMID: 38552718 Review. - Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae.
Shi Q, Yang H, Chen Y, Zheng N, Li X, Wang X, Ding W, Zhang B. Shi Q, et al. Int J Mol Sci. 2023 Jul 4;24(13):11099. doi: 10.3390/ijms241311099. Int J Mol Sci. 2023. PMID: 37446277 Free PMC article. - Imaging Approaches to Investigate Pathophysiological Mechanisms of Brain Disease in Zebrafish.
Turrini L, Roschi L, de Vito G, Pavone FS, Vanzi F. Turrini L, et al. Int J Mol Sci. 2023 Jun 7;24(12):9833. doi: 10.3390/ijms24129833. Int J Mol Sci. 2023. PMID: 37372981 Free PMC article. Review. - Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism.
Ichikawa S, Abe R, Fujimoto H, Higashi K, Zang L, Nakayama H, Matsuoka I, Shimada Y. Ichikawa S, et al. Front Microbiol. 2023 Feb 16;14:1079187. doi: 10.3389/fmicb.2023.1079187. eCollection 2023. Front Microbiol. 2023. PMID: 36876090 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources