Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide - PubMed (original) (raw)

Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide

J I Koenig et al. Endocrinology. 1990 Jun.

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Abstract

Using a specific antiserum recognizing recombinant rat interleukin-1 beta (IL-1 beta), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1 beta cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1 beta message after the administration of bacterial lipopolysaccharide, raises the possibility that IL-1 beta may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.

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