SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics - PubMed (original) (raw)

SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics

Filip Bielejec et al. Bioinformatics. 2011.

Abstract

Summary: SPREAD is a user-friendly, cross-platform application to analyze and visualize Bayesian phylogeographic reconstructions incorporating spatial-temporal diffusion. The software maps phylogenies annotated with both discrete and continuous spatial information and can export high-dimensional posterior summaries to keyhole markup language (KML) for animation of the spatial diffusion through time in virtual globe software. In addition, SPREAD implements Bayes factor calculation to evaluate the support for hypotheses of historical diffusion among pairs of discrete locations based on Bayesian stochastic search variable selection estimates. SPREAD takes advantage of multicore architectures to process large joint posterior distributions of phylogenies and their spatial diffusion and produces visualizations as compelling and interpretable statistical summaries for the different spatial projections.

Availability: SPREAD is licensed under the GNU Lesser GPL and its source code is freely available as a GitHub repository: https://github.com/phylogeography/SPREAD CONTACT: filip.bielejec@rega.kuleuven.be.

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Figures

Fig. 1.

Fig. 1.

Screenshot of SPREAD. This example visualizes the phylogeographic history of rabies among raccoons along the Eastern US seaboard under a continuous diffusion model. Such visualizations allow users to quickly inspect key evolutionary changes in their geographic context. Further generation of KML output enables interactive exploration in the time dimension as well in freely available virtual globe software, such as

Google Earth

(on the right).

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