Prestorage leukoreduction abrogates the detrimental effect of aging on packed red cells transfused after trauma: a prospective cohort study - PubMed (original) (raw)
Clinical Trial
Prestorage leukoreduction abrogates the detrimental effect of aging on packed red cells transfused after trauma: a prospective cohort study
Herb A Phelan et al. Am J Surg. 2012 Feb.
Abstract
Background: The aim of this study was to prospectively duplicate previous retrospective findings showing that prestorage leukoreduction blunts the detrimental effect of aging on banked packed red blood cells transfused after injury.
Methods: Over 19 months, trauma patients transfused with ≥4 U of packed red blood cells and surviving ≥24 hours were followed. The age of each unit was collected.
Results: The cohort consisted of 153 patients. All models showed no association between advancing blood age and the likelihood of developing multiple-organ dysfunction syndrome or infections, regardless of whether the mean age of blood was analyzed as a continuous variable, as a percentage of blood received that was <14 days old, or as a dichotomized value >14 or <14 days old.
Conclusions: This prospective study duplicates previous retrospective findings of an abrogation of the detrimental effects of advancing mean packed red blood cell age on outcomes after trauma by performing prestorage leukoreduction.
Copyright © 2012 Elsevier Inc. All rights reserved.
Figures
Fig 1. Time to infection for patients with and without MODS
MODS patients had a significantly higher probability of infection (p=0.012) with a risk of slightly more than twice that of patients without MODS.
Fig 2. Odds ratios of MODS and infectious complications with 95% Confidence Intervals in the logistic regression models
PRBC= Packed Red Blood; ISS= Injury Severity Score; AIS= Abbreviated Injury Score
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