Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes - PubMed (original) (raw)
Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes
Ayumu Hirata et al. Atherosclerosis. 2011 Dec.
Abstract
Objective: Patients with type 2 diabetes mellitus (T2DM) are at risk of polyvascular comorbidities and poor prognosis. Non-invasive techniques for early prediction of coronary artery disease (CAD) are desirable to prevent cardiovascular events in these patients. The aim of the present study was to investigate the association between CAD and systemic arteriosclerosis by qualitative vascular ultrasonography.
Methods: The study subjects were 102 consecutive outpatients with T2DM [males/females = 60/42, age: mean ± SD 67 ± 9 (range, 40-85) years] evaluated by vascular ultrasonography for arteriosclerosis in the abdominal aorta, carotid, renal, and common iliac arteries. The total number of detected arteriosclerotic vascular lesions in the four arteries was determined. CAD was diagnosed by two cardiologists using either stress electrocardiography, myocardial scintigraphy, multi-detector row computed tomography or coronary angiography.
Results: Multiple arteriosclerotic vascular lesions (>1) were detected in 64 (63%) patients. The total systemic vascular score was significantly higher in patients with CAD than those without (average score 2.7 versus 1.0, p < 0.0001). None of the CAD patients had a total score of 0. Age- and sex-adjusted multiple logistic regression analysis identified total score of ≥ 2 as the only predictor of CAD (p < 0.001). The sensitivity, specificity, positive and negative predictive values for total systemic vascular score in the prediction of CAD were 98%, 77%, 83%, and 97%, respectively, which were better than those for carotid mean and maximum intima-media thickness.
Conclusion: Non-invasive qualitative evaluation of systemic arteriosclerosis by the total systemic vascular score is potentially useful for the early prediction of CAD in T2DM patients.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Similar articles
- Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease.
Irie Y, Katakami N, Kaneto H, Kasami R, Sumitsuji S, Yamasaki K, Tachibana K, Kuroda T, Sakamoto K, Umayahara Y, Ueda Y, Kosugi K, Shimomura I. Irie Y, et al. Atherosclerosis. 2012 Apr;221(2):438-44. doi: 10.1016/j.atherosclerosis.2012.01.022. Epub 2012 Jan 21. Atherosclerosis. 2012. PMID: 22321873 - Carotid plaque burden as a measure of subclinical atherosclerosis: comparison with other tests for subclinical arterial disease in the High Risk Plaque BioImage study.
Sillesen H, Muntendam P, Adourian A, Entrekin R, Garcia M, Falk E, Fuster V. Sillesen H, et al. JACC Cardiovasc Imaging. 2012 Jul;5(7):681-9. doi: 10.1016/j.jcmg.2012.03.013. JACC Cardiovasc Imaging. 2012. PMID: 22789936 - Prognostic implications of myocardial perfusion imaging and coronary calcium score in a Macedonian cohort of asymptomatic patients with type 2 diabetes.
Mitevska IP, Baneva N, Srbinovska E, Stojanovska L, Apostolopoulos V, Bosevski M. Mitevska IP, et al. Diab Vasc Dis Res. 2017 Jul;14(4):285-294. doi: 10.1177/1479164116680776. Epub 2017 Apr 8. Diab Vasc Dis Res. 2017. PMID: 28393566 - Diagnostic and prognostic testing to evaluate coronary artery disease in patients with diabetes mellitus.
Patel NB, Balady GJ. Patel NB, et al. Rev Endocr Metab Disord. 2010 Mar;11(1):11-20. doi: 10.1007/s11154-010-9129-1. Rev Endocr Metab Disord. 2010. PMID: 20225090 Review. - Non-invasive cardiac imaging techniques and vascular tools for the assessment of cardiovascular disease in type 2 diabetes mellitus.
Djaberi R, Beishuizen ED, Pereira AM, Rabelink TJ, Smit JW, Tamsma JT, Huisman MV, Jukema JW. Djaberi R, et al. Diabetologia. 2008 Sep;51(9):1581-93. doi: 10.1007/s00125-008-1062-4. Epub 2008 Jul 8. Diabetologia. 2008. PMID: 18607561 Free PMC article. Review.
Cited by
- Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN.
Liu Y, Liu LY, Jia Y, Sun YY, Ma FZ. Liu Y, et al. Biosci Rep. 2019 Jul 2;39(7):BSR20181852. doi: 10.1042/BSR20181852. Print 2019 Jul 31. Biosci Rep. 2019. PMID: 31182467 Free PMC article. Retracted. - Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation.
Murai J, Nishizawa H, Otsuka A, Fukuda S, Tanaka Y, Nagao H, Sakai Y, Suzuki M, Yokota S, Tada H, Doi M, Fujishima Y, Kita S, Funahashi T, Maeda N, Nakamura T, Shimomura I. Murai J, et al. Cardiovasc Diabetol. 2018 Aug 4;17(1):112. doi: 10.1186/s12933-018-0755-3. Cardiovasc Diabetol. 2018. PMID: 30077183 Free PMC article. - Characteristics of sleep-wake cycle and sleep duration in Japanese type 2 diabetes patients with visceral fat accumulation.
Fukuda S, Hirata A, Nishizawa H, Nagao H, Kimura T, Fujishima Y, Yamaoka M, Kozawa J, Imagawa A, Funahashi T, Maeda N, Shimomura I. Fukuda S, et al. J Diabetes Investig. 2018 Jan;9(1):63-68. doi: 10.1111/jdi.12643. Epub 2017 Mar 31. J Diabetes Investig. 2018. PMID: 28178395 Free PMC article. - The coexistence of carotid and lower extremity atherosclerosis further increases cardio-cerebrovascular risk in type 2 diabetes.
Li MF, Zhao CC, Li TT, Tu YF, Lu JX, Zhang R, Chen MY, Bao YQ, Li LX, Jia WP. Li MF, et al. Cardiovasc Diabetol. 2016 Mar 5;15:43. doi: 10.1186/s12933-016-0360-2. Cardiovasc Diabetol. 2016. PMID: 26944724 Free PMC article. - Cognitive dysfunction in type 2 diabetes patients accompanied with obstructive sleep apnea syndrome.
Li H, Gong Q, Shao J, Liu X, Zhao Y. Li H, et al. Pak J Med Sci. 2014 Nov-Dec;30(6):1388-92. doi: 10.12669/pjms.306.5861. Pak J Med Sci. 2014. PMID: 25674144 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous