Self-replication of enterochromaffin-like cells in the mouse stomach - PubMed (original) (raw)
Self-replication of enterochromaffin-like cells in the mouse stomach
Y Tielemans et al. Digestion. 1990.
Abstract
The renewal mechanisms for enterochromaffin-like (ECL) cells, the predominating endocrine cell population in the oxyntic mucosa of the stomach, were investigated in the mouse. The ECL cells were selectively demonstrated by immunostaining using histamine antibodies. Under basal conditions, when observed during the night, ECL cells in mitosis could be seen. This observation proved their ability to divide. Autoradiography after a single pulse and after multiple injections of 3H-thymidine made it possible to study some of their cytokinetic characteristics. The observed replication rate of the labeled ECL cells suggested that self-replication is the main mechanism by which the ECL cell population is renewed. The time interval between two successive divisions of labeled ECL cells was estimated to be around 60 days. Since ECL cells proliferate through mitosis, it may be expected that specific mitogenic stimuli might promote the induction of ECL cell hyperplasia and eventually ECL cell tumors (gastric carcinoids).
Similar articles
- Proliferation of enterochromaffinlike cells in omeprazole-treated hypergastrinemic rats.
Tielemans Y, Håkanson R, Sundler F, Willems G. Tielemans Y, et al. Gastroenterology. 1989 Mar;96(3):723-9. Gastroenterology. 1989. PMID: 2644152 - Serum gastrin concentration affects the self replication rate of the enterochromaffin like cells in the rat stomach.
Tielemans Y, Axelson J, Sundler F, Willems G, Håkanson R. Tielemans Y, et al. Gut. 1990 Mar;31(3):274-8. doi: 10.1136/gut.31.3.274. Gut. 1990. PMID: 2323588 Free PMC article. - Activation and hyperplasia of gastrin and enterochromaffin-like cells in the stomach.
Håkanson R, Böttcher G, Sundler F, Vallgren S. Håkanson R, et al. Digestion. 1986;35 Suppl 1:23-41. doi: 10.1159/000199380. Digestion. 1986. PMID: 3539678 Review. - Hypergastrinemia and gastric enterochromaffin-like cells.
Bordi C, D'Adda T, Azzoni C, Pilato FP, Caruana P. Bordi C, et al. Am J Surg Pathol. 1995;19 Suppl 1:S8-19. Am J Surg Pathol. 1995. PMID: 7762739 Review.
Cited by
- The Enterochromaffin-like [ECL] Cell-Central in Gastric Physiology and Pathology.
Waldum HL, Sørdal ØF, Mjønes PG. Waldum HL, et al. Int J Mol Sci. 2019 May 17;20(10):2444. doi: 10.3390/ijms20102444. Int J Mol Sci. 2019. PMID: 31108898 Free PMC article. Review. - Correct Identification of Cell of Origin May Explain Many Aspects of Cancer: The Role of Neuroendocrine Cells as Exemplified from the Stomach.
Waldum H, Mjønes PG. Waldum H, et al. Int J Mol Sci. 2020 Aug 11;21(16):5751. doi: 10.3390/ijms21165751. Int J Mol Sci. 2020. PMID: 32796591 Free PMC article. Review. - The biology and pathobiology of the ECL cells.
Håkanson R, Tielemans Y, Chen D, Andersson K, Ryberg B, Mattsson H, Sundler F. Håkanson R, et al. Yale J Biol Med. 1992 Nov-Dec;65(6):761-74; discussion 827-9. Yale J Biol Med. 1992. PMID: 1341077 Free PMC article. Review. - Acid suppression and gastric mucosal cell biology.
Delle Fave G, Helander H, Holt S, Modlin IM, Powers R, Solcia E, Soll A, Tielemans Y, Wright NA. Delle Fave G, et al. Dig Dis Sci. 1994 Sep;39(9):1843-52. doi: 10.1007/BF02088113. Dig Dis Sci. 1994. PMID: 8082489 Review. - Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift.
Waldum HL, Öberg K, Sørdal ØF, Sandvik AK, Gustafsson BI, Mjønes P, Fossmark R. Waldum HL, et al. Therap Adv Gastroenterol. 2018 May 27;11:1756284818775054. doi: 10.1177/1756284818775054. eCollection 2018. Therap Adv Gastroenterol. 2018. PMID: 29872453 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources