The chemokine system and cancer - PubMed (original) (raw)

Review

. 2012 Jan;226(2):148-57.

doi: 10.1002/path.3029. Epub 2011 Nov 23.

Affiliations

• PMID: 21989643
• DOI: 10.1002/path.3029

Review

The chemokine system and cancer

Frances R Balkwill. J Pathol. 2012 Jan.

Abstract

Chemokines (chemo-attractant cytokines) are a group of small proteins that act together with their cell surface receptors, in development, normal physiology and immune responses, to direct cells to specific locations throughout the body. Cancer cells acquire the ability to subvert the chemokine system, such that these molecules and their receptors become important regulators of cell movement into and out of the tumour microenvironment and major players in cancer biology.

Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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