Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis - PubMed (original) (raw)
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. 2011 Oct 18;20(4):415-6.
doi: 10.1016/j.ccr.2011.10.003.
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- PMID: 22014565
- DOI: 10.1016/j.ccr.2011.10.003
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Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis
Angela Bowman et al. Cancer Cell. 2011.
Free article
Abstract
Genetic alterations in the Wnt/β-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates β-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/β-catenin pathway activation.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
- FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.
Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S. Zhang N, et al. Cancer Cell. 2011 Oct 18;20(4):427-42. doi: 10.1016/j.ccr.2011.08.016. Cancer Cell. 2011. PMID: 22014570 Free PMC article.
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