Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone - PubMed (original) (raw)

Effects of icv administration of hamster GnIH peptides on plasma LH and FSH concentrations in LD and SD. A, RFRP-1 (100 or 500 pmol), RFRP-3 (100 or 500 pmol), or vehicle was administered icv to hamsters kept in LD, and LH concentration was measured in the plasma at 5 min after administration. Each column and the vertical line represent the mean ±

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(n = 4). ***, P < 0.001; **, P < 0.01; *, P < 0.05 vs. vehicle. ††, P < 0.01, RFRP-1 100 pmol vs. RFRP-3 100 pmol. Statistical differences were analyzed by one-way ANOVA, followed by Bonferroni's multiple range test. B, RFRP-1 (100 or 500 pmol), RFRP-3 (100 or 500 pmol), or vehicle was administered icv to hamsters kept in SD, and LH concentration was measured in the plasma at 5 min after administration. Each column and the vertical line represent the mean ±

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(n = 4). C, RFRP-1 (100 or 500 pmol), RFRP-3 (100 or 500 pmol), or vehicle was administered icv to hamsters kept in LD, and LH concentration was measured in the plasma at 30 min after administration. Each column and the vertical line represent the mean ±

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(n = 4). *, P < 0.05 vs. vehicle. D, RFRP-1 (500 pmol), RFRP-3 (500 pmol), or vehicle was administered icv to hamsters maintained in SD, and LH concentration was measured in the plasma at 30 min after administration. Each column and the vertical line represent the mean ±

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(n = 4). *, P < 0.05 vs. vehicle. ††, P < 0.01, RFRP-1 500 pmol vs. RFRP-3 500 pmol. E, RFRP-1 (100 or 500 pmol), RFRP-3 (100 or 500 pmol), or vehicle was administered icv to hamsters maintained in LD, and FSH concentration was measured in the plasma at 5 min after administration. Each column and the vertical line represent the mean ±

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(n = 4). F, RFRP-1 (500 pmol), RFRP-3 (500 pmol), or vehicle was administered icv to hamsters maintained in SD, and FSH concentration was measured in the plasma at 30 min after administration. Each column and the vertical line represent the mean ±

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(n = 4).