Nitric oxide during altitude acclimatization - PubMed (original) (raw)

Nitric oxide during altitude acclimatization

Allison J Janocha et al. N Engl J Med. 2011.

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Figure 1

Figure 1. Acclimatization Responses at High Altitude

Panel A shows the altitudes reached on each of the 19 days in the study; the letter S signifies the days on which samples were collected (days 2, 5, 13, and 19). Panel B shows that the arterial oxygen saturation decreased with ascent, Panel C that erythropoietin (EPO) levels increased at 3440 m and remained elevated at 5050 m before returning to baseline levels at 1300 m. In Panels D, E, and F, levels of salivary, urinary, and serum nitrogen oxides, respectively, increase at 3440 m before falling to baseline values at 5050 m. In contrast, as shown in Panel G, serum levels of nitrite continued to increase with ascent, remained elevated, and then returned to baseline levels at 1300 m. In Panels H and I, the molar ratios of _S_-nitrosohemoglobin (SNO:Hb) and iron nitrosyl hemoglobin (FeNO:Hb) increased with ascent and returned to baseline values at 1300 m. (Methods of measurement are provided in the Supplementary Appendix.) Asterisks indicate that P<0.05 for the comparison with baseline values by pairwise t-test. T bars indicate standard errors.

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