MINT, the molecular interaction database: 2012 update - PubMed (original) (raw)

. 2012 Jan;40(Database issue):D857-61.

doi: 10.1093/nar/gkr930. Epub 2011 Nov 16.

Leonardo Briganti, Daniele Peluso, Livia Perfetto, Marta Iannuccelli, Eugenia Galeota, Francesca Sacco, Anita Palma, Aurelio Pio Nardozza, Elena Santonico, Luisa Castagnoli, Gianni Cesareni

Affiliations

• PMID: 22096227
• PMCID: PMC3244991
• DOI: 10.1093/nar/gkr930

MINT, the molecular interaction database: 2012 update

Luana Licata et al. Nucleic Acids Res. 2012 Jan.

Abstract

The Molecular INTeraction Database (MINT, http://mint.bio.uniroma2.it/mint/) is a public repository for protein-protein interactions (PPI) reported in peer-reviewed journals. The database grows steadily over the years and at September 2011 contains approximately 235,000 binary interactions captured from over 4750 publications. The web interface allows the users to search, visualize and download interactions data. MINT is one of the members of the International Molecular Exchange consortium (IMEx) and adopts the Molecular Interaction Ontology of the Proteomics Standard Initiative (PSI-MI) standards for curation and data exchange. MINT data are freely accessible and downloadable at http://mint.bio.uniroma2.it/mint/download.do. We report here the growth of the database, the major changes in curation policy and a new algorithm to assign a confidence to each interaction.

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Figures

Figure 1.

MINT growth. The bar diagrams illustrate the increase in number of MINT entries (A) and of curated manuscripts (B) since the latest update in 2009.

Figure 2.

‘Curation-depth’ and ‘Curation-coverage’**.** The pie charts illustrate the fraction of MINT entries that are labelled with different tags according to curation depth (A) and curation coverage (B).

Figure 3.

Scoring system**.** The two bar diagrams illustrate the number of interactions as a function of the score according to the original algorithm (A) or to the one presented here (B).

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