Immune profiling of Alzheimer patients - PubMed (original) (raw)

Comparative Study

. 2012 Jan 18;242(1-2):52-9.

doi: 10.1016/j.jneuroim.2011.11.005. Epub 2011 Dec 6.

Anis Larbi, David Goldeck, Giuseppina Colonna-Romano, Silvio Buffa, Matteo Bulati, Graziella Rubino, Francesco Iemolo, Giuseppina Candore, Calogero Caruso, Evelyna Derhovanessian, Graham Pawelec

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Comparative Study

Immune profiling of Alzheimer patients

Mariavaleria Pellicanò et al. J Neuroimmunol. 2012.

Free article

Abstract

Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease.

Copyright © 2011 Elsevier B.V. All rights reserved.

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