Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury - PubMed (original) (raw)
doi: 10.1038/ki.2011.405. Epub 2011 Dec 7.
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- PMID: 22157656
- DOI: 10.1038/ki.2011.405
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Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury
Ion D Bucaloiu et al. Kidney Int. 2012 Mar.
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Abstract
Acute kidney injury increases mortality risk among those with established chronic kidney disease. In this study we used a propensity score-matched cohort method to retrospectively evaluate the risks of death and de novo chronic kidney disease after reversible, hospital-associated acute kidney injury among patients with normal pre-hospitalization kidney function. Of 30,207 discharged patients alive at 90 days, 1610 with reversible acute kidney injury that resolved within the 90 days were successfully matched across multiple parameters with 3652 control patients who had not experienced acute kidney injury. Median follow-up was 3.3 and 3.4 years (injured and control groups, respectively). In Cox proportional hazard models, the risk of death associated with reversible acute kidney injury was significant (hazard ratio 1.50); however, adjustment for the development of chronic kidney injury during follow-up attenuated this risk (hazard ratio 1.18). Reversible acute kidney injury was associated with a significant risk of de novo chronic kidney disease (hazard ratio 1.91). Thus, a resolved episode of hospital-associated acute kidney injury has important implications for the longitudinal surveillance of patients without preexisting, clinically evident kidney disease.
Comment in
- Chronic-on-acute kidney injury.
Palevsky PM. Palevsky PM. Kidney Int. 2012 Mar;81(5):430-1. doi: 10.1038/ki.2011.435. Kidney Int. 2012. PMID: 22333743 - Renal function after elective total hip replacement.
Perregaard H, Damholt MB, Solgaard S, Petersen MB. Perregaard H, et al. Acta Orthop. 2016 Jun;87(3):235-8. doi: 10.3109/17453674.2016.1155130. Epub 2016 Mar 3. Acta Orthop. 2016. PMID: 26937782 Free PMC article.
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