Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats - PubMed (original) (raw)

Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats

U McKeever et al. Proc Natl Acad Sci U S A. 1990 Oct.

Abstract

We describe the induction of autoimmune diabetes, insulitis, and thyroiditis in athymic rats following injections of major histocompatibility complex compatible spleen cells. Lymphocytes with these capabilities were found in normal rats of the YOS, WAG, PVG, and diabetes-resistant BB strains, and in diabetes-prone BB rats. Adoptive transfer was facilitated by prior in vivo depletion of RT6.1+ regulatory T cells and in vitro mitogen activation of donor spleen cells. By RT6 depleting diabetes-resistant donors and using nude recipients, transfer of diabetes and thyroiditis was accomplished by using fresh, unstimulated spleen cells. The data suggest that organ-specific autoreactive cells may be present to various degrees but suppressed to a variable extent in many rat strains. The equilibrium between autoreactive and regulatory cells appears to determine the expression of autoimmunity.

PubMed Disclaimer

Similar articles

• Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats.
  Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP, Rossini AA. Gottlieb PA, et al. Diabetologia. 1991 May;34(5):296-300. doi: 10.1007/BF00404999. Diabetologia. 1991. PMID: 1864483
• Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
  Whalen BJ, Greiner DL, Mordes JP, Rossini AA. Whalen BJ, et al. J Autoimmun. 1994 Dec;7(6):819-31. doi: 10.1006/jaut.1994.1065. J Autoimmun. 1994. PMID: 7888038
• Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat.
  Ellerman KE, Richards CA, Guberski DL, Shek WR, Like AA. Ellerman KE, et al. Diabetes. 1996 May;45(5):557-62. doi: 10.2337/diab.45.5.557. Diabetes. 1996. PMID: 8621003
• Autoimmune endocrine diseases.
  De Baets MH. De Baets MH. Year Immunol. 1989;4:264-75. Year Immunol. 1989. PMID: 2564710 Review. No abstract available.
• The BB rat.
  Mordes JP, Desemone J, Rossini AA. Mordes JP, et al. Diabetes Metab Rev. 1987 Jul;3(3):725-50. doi: 10.1002/dmr.5610030307. Diabetes Metab Rev. 1987. PMID: 3301238 Review. No abstract available.

Cited by

• Prevention of insulin-dependent diabetes mellitus--wishful thinking, or reality?
  Palmer J. Palmer J. West J Med. 1996 Mar;164(3):277-8. West J Med. 1996. PMID: 8775949 Free PMC article. No abstract available.
• The immunologic insult in type 1 diabetes.
  Honeyman MC, Harrison LC. Honeyman MC, et al. Springer Semin Immunopathol. 1993;14(3):253-74. doi: 10.1007/BF00195977. Springer Semin Immunopathol. 1993. PMID: 8438209 Review. No abstract available.
• Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.
  Arndt T, Wedekind D, Weiss H, Tiedge M, Lenzen S, Hedrich HJ, Jörns A. Arndt T, et al. Diabetologia. 2009 Jul;52(7):1381-90. doi: 10.1007/s00125-009-1348-1. Epub 2009 Apr 15. Diabetologia. 2009. PMID: 19367386
• Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats.
  Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP, Rossini AA. Gottlieb PA, et al. Diabetologia. 1991 May;34(5):296-300. doi: 10.1007/BF00404999. Diabetologia. 1991. PMID: 1864483

References

1. 1. J Exp Med. 1985 Jan 1;161(1):72-87 - PubMed
2. 1. J Immunol. 1983 Jun;130(6):2798-803 - PubMed
3. 1. J Immunol. 1986 Jan;136(1):148-51 - PubMed
4. 1. Science. 1986 Feb 14;231(4739):733-5 - PubMed
5. 1. J Immunol. 1986 May 1;136(9):3254-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Medical

  • MedlinePlus Health Information