A new 'Linc' between noncoding RNAs and blood development - PubMed (original) (raw)

Comment

A new 'Linc' between noncoding RNAs and blood development

Vikram R Paralkar et al. Genes Dev. 2011.

Abstract

Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.

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Figures

Figure 1.

A potential mechanism for LincRNA-EPS action in erythropoiesis. (A) The study by Hu et al. (2011) demonstrates that LincRNA-EPS represses Pycard to inhibit apoptosis of RBC progenitors. LincRNA-EPS may bind the Pycard gene and inhibit its transcription by recruiting transcriptional repressor complexes. (B) Knockdown of LincRNA-EPS permits transcription of Pycard, which activates intercellular caspases and induces apoptosis.

Comment on

Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation.
Hu W, Yuan B, Flygare J, Lodish HF. Hu W, et al. Genes Dev. 2011 Dec 15;25(24):2573-8. doi: 10.1101/gad.178780.111. Epub 2011 Dec 8. Genes Dev. 2011. PMID: 22155924 Free PMC article.

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A new 'Linc' between noncoding RNAs and blood development - PubMed (original) (raw)