Autophagy as a therapeutic target for ischaemia /reperfusion injury? Concepts, controversies, and challenges - PubMed (original) (raw)
Review
. 2012 May 1;94(2):197-205.
doi: 10.1093/cvr/cvr358. Epub 2012 Jan 2.
Affiliations
- PMID: 22215722
- DOI: 10.1093/cvr/cvr358
Review
Autophagy as a therapeutic target for ischaemia /reperfusion injury? Concepts, controversies, and challenges
Karin Przyklenk et al. Cardiovasc Res. 2012.
Abstract
Autophagy is the tightly orchestrated cellular 'housekeeping' process responsible for the degradation and disposal of damaged and dysfunctional organelles and protein aggregates. In addition to its established basal role in the maintenance of normal cellular phenotype and function, there is growing interest in the concept that targeted modulation of autophagy under conditions of stress (most notably, ischaemia/reperfusion) may represent an adaptive mechanism and render the myocardium resistant to ischaemia/reperfusion injury. Our aims in this review are to: (i) provide a balanced overview of the emerging hypothesis that perturbation of autophagy may serve as a novel, intriguing, and powerful cardioprotective treatment strategy and (ii) summarize the controversies and challenges in exploiting autophagy as a therapeutic target for ischaemia/reperfusion injury.
Similar articles
- The role of autophagy in the heart.
Nishida K, Kyoi S, Yamaguchi O, Sadoshima J, Otsu K. Nishida K, et al. Cell Death Differ. 2009 Jan;16(1):31-8. doi: 10.1038/cdd.2008.163. Epub 2008 Nov 14. Cell Death Differ. 2009. PMID: 19008922 Review. - Activated STAT-1 pathway in the myocardium as a novel therapeutic target in ischaemia/reperfusion injury.
Stephanou A. Stephanou A. Eur Cytokine Netw. 2002 Oct-Dec;13(4):401-3. Eur Cytokine Netw. 2002. PMID: 12517719 Review. - Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury.
Dong Y, Undyala VV, Gottlieb RA, Mentzer RM Jr, Przyklenk K. Dong Y, et al. J Cardiovasc Pharmacol Ther. 2010 Sep;15(3):220-30. doi: 10.1177/1074248410370327. Epub 2010 Jul 1. J Cardiovasc Pharmacol Ther. 2010. PMID: 20595626 Review. - [Regulatory effects of traditional Chinese medicine on autophagy in myocardial ischemia reperfusion injury].
Zheng Q, Bao YM. Zheng Q, et al. Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(15):2925-2929. doi: 10.19540/j.cnki.cjcmm.20170714.010. Zhongguo Zhong Yao Za Zhi. 2017. PMID: 29139258 Review. Chinese. - Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.
Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA, Gustafsson AB. Hamacher-Brady A, et al. Cell Death Differ. 2007 Jan;14(1):146-57. doi: 10.1038/sj.cdd.4401936. Epub 2006 Apr 28. Cell Death Differ. 2007. PMID: 16645637
Cited by
- Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective.
Li S, Li F, Wang Y, Li W, Wu J, Hu X, Tang T, Liu X. Li S, et al. Drug Deliv. 2024 Dec;31(1):2298514. doi: 10.1080/10717544.2023.2298514. Epub 2023 Dec 26. Drug Deliv. 2024. PMID: 38147501 Free PMC article. Review. - Protein homeostasis in the aged and diseased heart.
Mainali N, Ayyadevara S, Ganne A, Shmookler Reis RJ, Mehta JL. Mainali N, et al. J Cardiovasc Aging. 2023;3(2):16. doi: 10.20517/jca.2023.4. Epub 2023 Mar 7. J Cardiovasc Aging. 2023. PMID: 37092014 Free PMC article. - Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury.
Farzaei MH, Ramezani-Aliakbari F, Ramezani-Aliakbari M, Zarei M, Komaki A, Shahidi S, Sarihi A, Salehi I. Farzaei MH, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Aug;396(8):1633-1646. doi: 10.1007/s00210-023-02469-7. Epub 2023 Mar 27. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 36971866 Review. - Angiotensin receptor-neprilysin inhibitor attenuates ischemia-hypoxia-induced myocardial injury via inhibition of autophagy.
An J, Wang W, Guo Y, Wang C, Bao Q, Jia Y. An J, et al. Am J Transl Res. 2022 Dec 15;14(12):8611-8620. eCollection 2022. Am J Transl Res. 2022. PMID: 36628240 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources