Monitoring of cellular senescence by DNA-methylation at specific CpG sites - PubMed (original) (raw)

Monitoring of cellular senescence by DNA-methylation at specific CpG sites

Carmen M Koch et al. Aging Cell. 2012 Apr.

Free article

Abstract

Replicative senescence has fundamental implications on cell morphology, proliferation, and differentiation potential. Here, we describe a simple method to track long-term culture based on continuous DNA-methylation changes at six specific CpG sites. This epigenetic senescence signature can be used as biomarker for various cell types to predict the state of cellular senescence with regard to the number of passages, population doublings, or days of in vitro culture.

© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.

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