Advances in Aspergillus secondary metabolite research in the post-genomic era - PubMed (original) (raw)
Review
Advances in Aspergillus secondary metabolite research in the post-genomic era
James F Sanchez et al. Nat Prod Rep. 2012 Mar.
Abstract
This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.
Figures
Scheme 1
The biosynthetic pathway for austinol and dehydroaustinol.
Scheme 2
The biosynthetic pathway for acetylaszonalenin.
Scheme 3
The biosynthetic pathway for terrequinone A.
Scheme 4
The biosynthetic pathway for prenyl xanthones in A. nidulans.
Scheme 5
The biosynthetic pathway for gliotoxin.
Scheme 6
The biosynthetic pathway for fumigaclavine C.
Scheme 7
The biosynthetic pathway for fumiquinazoline D.
Scheme 8
The biosynthetic pathway for fumitremorgin A.
Scheme 9
The proposed biosynthetic pathway for CPA.
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