Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease - PubMed (original) (raw)
Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease
Han-Lin Chiang et al. Parkinsonism Relat Disord. 2012 May.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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