P-bodies and their functions during mRNA cell cycle: mini-review - PubMed (original) (raw)
Review
doi: 10.1002/cbf.2804. Epub 2012 Jan 17.
Affiliations
- PMID: 22249943
- DOI: 10.1002/cbf.2804
Review
P-bodies and their functions during mRNA cell cycle: mini-review
Marta Olszewska et al. Cell Biochem Funct. 2012 Apr.
Abstract
P-bodies (processing bodies) are observed in different organisms such as yeast, Caenorhabditis elegans and mammals. A typical eukaryotic cell contains several types of spatially formed granules, such as P-bodies, stress granules and a variety of ribonucleoprotein bodies. These microdomains play important role in mRNA processing, including RNA interference, repression of translation and mRNA decay. The P-bodies components as well as stress granules may play an important role in host defense against viral infection. The complete set of P-bodies protein elements is still poor known. They contain conserved protein core limited to different organisms or to stress status of the cell. P-bodies are related also to some neuronal mRNA granules as well as to maternal RNA granules or male germ cell granules. In this mini-review, we focus on the structure of P-bodies and their function in the mRNA utilization and processing because of the high mRNA's dynamics between different cellular compartments and its key role in modulation of gene expression.
Copyright © 2012 John Wiley & Sons, Ltd.
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