The association of cardiovascular disease and metabolic syndrome with nephrolithiasis - PubMed (original) (raw)
Review
The association of cardiovascular disease and metabolic syndrome with nephrolithiasis
Jessica N Lange et al. Curr Opin Urol. 2012 Mar.
Abstract
Purpose of review: This review describes the relationship between nephrolithiasis, vascular disease and metabolic syndrome.
Recent findings: There is increasing evidence that kidney stone formation is associated with a number of systemic problems including cardiovascular disease, metabolic syndrome and its components. Some of these associations are bidirectional. The reasons for these associations are not totally clear, but potential factors include metabolic responses associated with these disorders that promote a stone forming milieu in urine, environmental factors such as diet, oxidative stress and inflammation and molecular changes impacting the transport of certain analytes in urine.
Summary: Urologists need to be cognizant of these associations as they may be able to contribute to an early diagnosis of a significant medical problem, or provide counseling to patients to prevent their occurrence.
Conflict of interest statement
Conflicts of interest
The authors of this study have no conflicts of interest. This study was supported by National Institutes of Health Grant R01 DK62284.
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References
- Reiner AP, Kahn A, Eisner BH, et al.Kidney stones and subclinical athero sclerosis in young adults: the CARDIA study. J Urol 2011; 185:920–925.
■ This cohort study demonstrates that a history of nephrolithiasis is associated with the presence of sublinical atherosclerotic disease in young adults.
- Reiner AP, Kahn A, Eisner BH, et al.Kidney stones and subclinical athero sclerosis in young adults: the CARDIA study. J Urol 2011; 185:920–925.
- O’Leary DH, Polak JF, Kronmal RA, et al.Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study collaborative research group. N Engl J Med 1999; 340:14–22. - PubMed
- Rule AD, Roger VL, Melton LJ 3rd, et al.Kidney stones associate with increased risk for myocardial infarction. J Am Soc Nephrol 2010; 21:1641–1644.
■■ This case–control study demonstrates that kidney stone formation is associated with a significant risk for sustaining a myocardial infarction.
- Rule AD, Roger VL, Melton LJ 3rd, et al.Kidney stones associate with increased risk for myocardial infarction. J Am Soc Nephrol 2010; 21:1641–1644.
- Domingos F, Serra A. Nephrolithiasis is associated with an increased pre valence of cardiovascular disease. Nephrol Dial Transplant 2011; 26:864–868.
■ This cohort study reveals that stone formers are at increased risk of suffering from hypertension, diabetes mellitus, myocardial infarction and stroke compared with the general population.
- Domingos F, Serra A. Nephrolithiasis is associated with an increased pre valence of cardiovascular disease. Nephrol Dial Transplant 2011; 26:864–868.
- Hamano S, Nakatsu H, Suzuki N, et al.Kidney stone disease and risk factors for coronary heart disease. Int J Urol 2005; 12:859–863. - PubMed
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