UPEC hemolysin: more than just for making holes - PubMed (original) (raw)

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UPEC hemolysin: more than just for making holes

Sheryl S Justice et al. Cell Host Microbe. 2012.

Abstract

During acute cystitis, uropathogenic Escherichia coli (UPEC) induce bladder epithelial cell exfoliation, which eliminates infected cells and promotes UPEC dissemination. Dhakal and Mulvey (2012) uncover the mechanism that induces this exfoliation and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets multiple host pathways to facilitate infection.

Copyright © 2012 Elsevier Inc. All rights reserved.

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References

    1. Bishop BL, Duncan MJ, Song J, Li G, Zaas D, Abraham SN. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med. 2007;13:625–630. -PubMed
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