Effects of ipsapirone and cannabidiol on human experimental anxiety - PubMed (original) (raw)
Effects of ipsapirone and cannabidiol on human experimental anxiety
A W Zuardi et al. J Psychopharmacol. 1993 Jan.
Abstract
The effects of ipsapirone and cannabidiol (CBD) on healthy volunteers submitted to a simulated public speaking (SPS) test were compared with those of the anxiolytic benzodiazepine diazepam and placebo. Four independent groups of 10 subjects received, under a double-blind design, placebo or one of the following drugs: CBD (300 mg), diazepam (10 mg) or ipsapirone (5 mg). Subjective anxiety was evaluated through the Visual Analogue Mood Scale (VAMS) and the State-trait Anxiety Inventory (STAI). The VAMS anxiety factor showed that ipsapirone attenuated SPS-induced anxiety while CBD decreased anxiety after the SPS test. Diazepam, on the other hand, was anxiolytic before and after the SPS test, but had no effect on the increase in anxiety induced by the speech test. Only ipsapirone attenuated the increase in systolic blood pressure induced by the test. Significant sedative effects were only observed with diazepam. The results suggest that ipsapirone and CBD have anxiolytic properties in human volunteers submitted to a stressful situation.
Similar articles
- A simple simulated public speaking test for evaluating anxiolytic drugs.
Guimarães FS, Kohem CL, Gus G, Fillmann HS, de-Vecino MC, de-Paoli CL, Ribeiro AM, Teixeira CC, Wannmacher L. Guimarães FS, et al. Braz J Med Biol Res. 1989;22(9):1083-9. Braz J Med Biol Res. 1989. PMID: 2699823 Clinical Trial. - Effect of chlorimipramine and maprotiline on experimental anxiety in humans.
Guimarães FS, Zuardi AW, Graeff FG. Guimarães FS, et al. J Psychopharmacol. 1987 Jan;1(3):184-92. doi: 10.1177/026988118700100305. J Psychopharmacol. 1987. PMID: 22158980 - Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.
Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA. Bergamaschi MM, et al. Neuropsychopharmacology. 2011 May;36(6):1219-26. doi: 10.1038/npp.2011.6. Epub 2011 Feb 9. Neuropsychopharmacology. 2011. PMID: 21307846 Free PMC article. Clinical Trial. - [Treatment of generalized anxiety: new pharmacologic approaches].
Boulenger JP. Boulenger JP. Encephale. 1995 Nov-Dec;21(6):459-66. Encephale. 1995. PMID: 8674471 Review. French. - Human experimental anxiety: actual public speaking induces more intense physiological responses than simulated public speaking.
Zuardi AW, Crippa JA, Hallak JE, Gorayeb R. Zuardi AW, et al. Braz J Psychiatry. 2013 Jul-Sep;35(3):248-53. doi: 10.1590/1516-4446-2012-0930. Braz J Psychiatry. 2013. PMID: 24142085 Review.
Cited by
- Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment.
Pérez R, Glaser T, Villegas C, Burgos V, Ulrich H, Paz C. Pérez R, et al. Life (Basel). 2022 Dec 15;12(12):2117. doi: 10.3390/life12122117. Life (Basel). 2022. PMID: 36556483 Free PMC article. Review. - Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.
Elms L, Shannon S, Hughes S, Lewis N. Elms L, et al. J Altern Complement Med. 2019 Apr;25(4):392-397. doi: 10.1089/acm.2018.0437. Epub 2018 Dec 13. J Altern Complement Med. 2019. PMID: 30543451 Free PMC article. - Evidence For Cannabidiol Modulation of Serotonergic Transmission in a Model of Osteoarthritis via in vivo PET Imaging and Behavioral Assessment.
Ding YS, Wang J, Kumar V, Ciaccio J, Dakhel S, Tan C, Kim J, Lee S, Katz-Lichtenstein H, Gironda Z, Mishkit O, Mroz J, Jackson R, Yoon G, Gamallo-Lana B, Klores M, Mar A. Ding YS, et al. Int J Innov Res Med Sci. 2022 Jun;7(6):254-271. doi: 10.23958/ijirms/vol07-i06/1418. Epub 2022 Jun 3. Int J Innov Res Med Sci. 2022. PMID: 37841504 Free PMC article. - Cannabis craving in response to laboratory-induced social stress among racially diverse cannabis users: The impact of social anxiety disorder.
Buckner JD, Zvolensky MJ, Ecker AH, Jeffries ER. Buckner JD, et al. J Psychopharmacol. 2016 Apr;30(4):363-9. doi: 10.1177/0269881116629115. Epub 2016 Feb 2. J Psychopharmacol. 2016. PMID: 26839322 Free PMC article. - Cannabidiol: pharmacology and therapeutic targets.
Britch SC, Babalonis S, Walsh SL. Britch SC, et al. Psychopharmacology (Berl). 2021 Jan;238(1):9-28. doi: 10.1007/s00213-020-05712-8. Epub 2020 Nov 21. Psychopharmacology (Berl). 2021. PMID: 33221931 Free PMC article. Review.
LinkOut - more resources
Full Text Sources
Other Literature Sources