RNA-guided genetic silencing systems in bacteria and archaea - PubMed (original) (raw)
Review
. 2012 Feb 15;482(7385):331-8.
doi: 10.1038/nature10886.
Affiliations
- PMID: 22337052
- DOI: 10.1038/nature10886
Review
RNA-guided genetic silencing systems in bacteria and archaea
Blake Wiedenheft et al. Nature. 2012.
Abstract
Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small RNAs are used to find and destroy foreign nucleic acids will provide new insights into the diverse mechanisms of RNA-controlled genetic silencing systems.
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