Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury - PubMed (original) (raw)

Review

doi: 10.1189/jlb.1011530. Epub 2012 Feb 17.

Affiliations

Review

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

Susanne Herold et al. J Leukoc Biol. 2012 Jul.

Abstract

Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.

PubMed Disclaimer

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources