Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex - PubMed (original) (raw)
Comparative Study
. 2012 Feb 26;15(4):607-12.
doi: 10.1038/nn.3051.
Affiliations
- PMID: 22366760
- DOI: 10.1038/nn.3051
Comparative Study
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex
Luc J Gentet et al. Nat Neurosci. 2012.
Abstract
Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake behaving mice. SOM neurons were spontaneously active during periods of quiet wakefulness. However, SOM neurons hyperpolarized and reduced action potential firing in response to both passive and active whisker sensing, in contrast with all other recorded types of nearby neurons, which were excited by sensory input. Optogenetic inhibition of SOM neurons increased burst firing in nearby excitatory neurons. We hypothesize that the spontaneous activity of SOM neurons during quiet wakefulness provides a tonic inhibition to the distal dendrites of excitatory pyramidal neurons. Conversely, the inhibition of SOM cells during active cortical processing likely enhances distal dendritic excitability, which may be important for top-down computations and sensorimotor integration.
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References
- Nature. 2009 Feb 26;457(7233):1142-5 - PubMed
- Nature. 1999 Mar 25;398(6725):338-41 - PubMed
- Front Neural Circuits. 2010 May 14;4:12 - PubMed
- Eur J Neurosci. 2007 Apr;25(8):2329-40 - PubMed
- Cell. 2010 Apr 2;141(1):154-165 - PubMed
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