Treatment of chronic hepatitis C genotype 1 with triple therapy comprising telaprevir or boceprevir - PubMed (original) (raw)
Review
. 2012 Feb 24:142:w13516.
doi: 10.4414/smw.2012.13516. eCollection 2012.
Collaborators, Affiliations
- PMID: 22367957
- DOI: 10.4414/smw.2012.13516
Free article
Review
Treatment of chronic hepatitis C genotype 1 with triple therapy comprising telaprevir or boceprevir
Swiss Association for the Study of the Liver. Swiss Med Wkly. 2012.
Free article
Abstract
Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. Two first-generation protease inhibitors, telaprevir and boceprevir, have recently been approved for the treatment of chronic hepatitis C genotype 1. Triple therapy comprising pegylated interferon-α, ribavirin and telaprevir or boceprevir increases sustained virological response rates to ~70% and allows to shorten treatment duration in ~½ of treatment-naïve patients with chronic hepatitis C genotype 1. Sustained virological response rates in treatment-experienced patients depend on the response to previous treatment, ranging from >80% in previous relapsers to ~30% in previous null responders. These advances come at the expense of new adverse effects and increased cost. In addition, treatment of chronic hepatitis C will become more complex. In these times of changing medical practice, the present expert opinion statement by the Swiss Association for the Study of the Liver shall provide guidance on the treatment of chronic hepatitis C with triple therapy comprising telaprevir or boceprevir.