Long-term synaptic potentiation in the amygdala - PubMed (original) (raw)
Long-term synaptic potentiation in the amygdala
P F Chapman et al. Synapse. 1990.
Abstract
The manner in which the circuitry of the amygdala computes its suspected mnemonic functions has been a mystery, partly because the cytoarchitectual complexity of this nuclear group has impeded the necessary cellular analysis. Here we report in vitro methods and results that may help elucidate cellular learning mechanisms in amygdala neurons. The amygdala brain slice preparation was combined with the single-electrode clamp (SEC) technique for intracellular analysis of membrane properties and synaptic responses. With respect to the active and passive membrane properties, we found considerable diversity among the population of cells that were sampled in the lateral and basolateral nuclei (n = 85). Synaptic inputs to these neurons were studied by stimulating the external capsule (EC), which was shown to produce a complex response that typically consisted of an excitatory followed by an inhibitory component. Based on several criteria, the excitatory component appeared to reflect a monosynaptic connection from the EC. One immediate goal was to discover whether the excitatory component displays the phenomenon of long-term potentiation (LTP)--a persistent increase in synaptic strength that can be induced by brief periods of the appropriate synaptic stimulation. Indeed, we found that high-frequency (100 Hz) stimulation of the EC induced LTP in 80% of the cells from which suitable recordings were obtained (n = 20). This finding of LTP in the amygdala is significant in regard to current efforts to explore linkages between this use-dependent form of synaptic plasticity and rapid kinds of associative learning.
Similar articles
- Fear memories induce a switch in stimulus response and signaling mechanisms for long-term potentiation in the lateral amygdala.
Schroeder BW, Shinnick-Gallagher P. Schroeder BW, et al. Eur J Neurosci. 2004 Jul;20(2):549-56. doi: 10.1111/j.1460-9568.2004.03517.x. Eur J Neurosci. 2004. PMID: 15233764 - Stabilization of thalamo-cortical long-term potentiation by the amygdala: cholinergic and transcription-dependent mechanisms.
Dringenberg HC, Kuo MC, Tomaszek S. Dringenberg HC, et al. Eur J Neurosci. 2004 Jul;20(2):557-65. doi: 10.1111/j.1460-9568.2004.03515.x. Eur J Neurosci. 2004. PMID: 15233765 - Fear learning induces persistent facilitation of amygdala synaptic transmission.
Schroeder BW, Shinnick-Gallagher P. Schroeder BW, et al. Eur J Neurosci. 2005 Oct;22(7):1775-83. doi: 10.1111/j.1460-9568.2005.04343.x. Eur J Neurosci. 2005. PMID: 16197518 - Induction mechanisms and modulation of bidirectional burst stimulation-induced synaptic plasticity in the hippocampus.
Clark K, Normann C. Clark K, et al. Eur J Neurosci. 2008 Jul;28(2):279-87. doi: 10.1111/j.1460-9568.2008.06337.x. Eur J Neurosci. 2008. PMID: 18702699 - Synaptic mechanisms of associative memory in the amygdala.
Maren S. Maren S. Neuron. 2005 Sep 15;47(6):783-6. doi: 10.1016/j.neuron.2005.08.009. Neuron. 2005. PMID: 16157273 Review.
Cited by
- Fear conditioning and extinction distinctively alter bidirectional synaptic plasticity within the amygdala of an animal model of post-traumatic stress disorder.
Park K, Park H, Chung C. Park K, et al. Neurobiol Stress. 2024 Jan 12;29:100606. doi: 10.1016/j.ynstr.2024.100606. eCollection 2024 Mar. Neurobiol Stress. 2024. PMID: 38292517 Free PMC article. - Initial Results of Tests Using GSR Biofeedback as a New Neurorehabilitation Technology Complementing Pharmacological Treatment of Patients with Schizophrenia.
Markiewicz R, Dobrowolska B. Markiewicz R, et al. Biomed Res Int. 2021 Jun 10;2021:5552937. doi: 10.1155/2021/5552937. eCollection 2021. Biomed Res Int. 2021. PMID: 34222472 Free PMC article. - BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING.
Bouton ME, Maren S, McNally GP. Bouton ME, et al. Physiol Rev. 2021 Apr 1;101(2):611-681. doi: 10.1152/physrev.00016.2020. Epub 2020 Sep 24. Physiol Rev. 2021. PMID: 32970967 Free PMC article. Review. - Amygdala: Neuroanatomical and Morphophysiological Features in Terms of Neurological and Neurodegenerative Diseases.
Nikolenko VN, Oganesyan MV, Rizaeva NA, Kudryashova VA, Nikitina AT, Pavliv MP, Shchedrina MA, Giller DB, Buligin KV, Sinelnikov MY. Nikolenko VN, et al. Brain Sci. 2020 Jul 31;10(8):502. doi: 10.3390/brainsci10080502. Brain Sci. 2020. PMID: 32751957 Free PMC article. Review. - General differential Hebbian learning: Capturing temporal relations between events in neural networks and the brain.
Zappacosta S, Mannella F, Mirolli M, Baldassarre G. Zappacosta S, et al. PLoS Comput Biol. 2018 Aug 28;14(8):e1006227. doi: 10.1371/journal.pcbi.1006227. eCollection 2018 Aug. PLoS Comput Biol. 2018. PMID: 30153263 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources