Cytokine gene polymorphisms and Parkinson's disease: a meta-analysis - PubMed (original) (raw)

Meta-Analysis

Cytokine gene polymorphisms and Parkinson's disease: a meta-analysis

Ketan Chu et al. Can J Neurol Sci. 2012 Jan.

Abstract

Background: Cytokines, which are involved in immunological responses, play and important role in the development and progression of Parkinson's disease (PD). The functional polymorphisms identified in cytokine genes are thought to influence PD risk. However the findings of studies investigating the association between cytokine gene polymorphisms and PD risk are still controversial. Therefore, we conducted a meta-analysis, in order to investigate the potential associations between cytokine gene polymorphisms and PD.

Methods: Studies of PD and cytokine polymorphisms were identified by searches of PubMed and PDGene. Pooled analyses were performed to assess the association between cytokine gene polymorphisms and PD.

Results: Our results indicated a positive association of TNFα -1031 CC genotype in overall analysis(CC vs. TT: OR=3.146; 95%CI: 1.631-6.070, p=0.008; CC vs. CT+TT: OR=3.187: 95%CI: 1.657-6.128,p=0.008), and an Asian subgroup, C variant(OR=1.328; 95%CI: 1.053-1.675, p=0.034) also conveyed an increased PD risk as well as CC genotype ( CC vs. TT: OR=3.207; 95%CI: 1.614-6.373, p=0.004; CC vs. CT+TT: OR=3.238; 95%CI: 1.636-6.410, p=0.004). A decreased risk for PD was associated with IL-6-174C allele (OR=0.761; 95%CI: 0.641-0.903, p=0.008) and IL-1RA VNTR 2 allele(OR=0.641; 95%CI: 0.456-0.826 p=0.004). For the polymorphisms of IL-1β C[-511]T, IL-1α C[-889]T , TNFα G[-308]A, and IL-10 G[-1082]A no significant association was found between the gene polymorphisms and PD risk.

Conclusions: Our meta-analysis suggested that gene polymorphisms of TNFα -1031, IL-6-174 and IL-1RA VNTR may be associated with PD risk. However, more large well-designed studies will be necessary to validate our findings.

PubMed Disclaimer

Comment in

IL6-gene variation in Parkinson's disease.
Sand PG. Sand PG. Can J Neurol Sci. 2013 Mar;40(2):268. doi: 10.1017/s0317167100017522. Can J Neurol Sci. 2013. PMID: 23573561 No abstract available.

Cited by

Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson's Disease?
Leal MC, Casabona JC, Puntel M, Pitossi FJ. Leal MC, et al. Front Cell Neurosci. 2013 Apr 29;7:53. doi: 10.3389/fncel.2013.00053. eCollection 2013. Front Cell Neurosci. 2013. PMID: 23641196 Free PMC article.
Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease.
Atilano ML, Hull A, Romila CA, Adams ML, Wildfire J, Ureña E, Dyson M, Ivan-Castillo-Quan J, Partridge L, Kinghorn KJ. Atilano ML, et al. PLoS Genet. 2023 Dec 21;19(12):e1011063. doi: 10.1371/journal.pgen.1011063. eCollection 2023 Dec. PLoS Genet. 2023. PMID: 38127816 Free PMC article.
Midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions.
Abellanas MA, Zamarbide M, Basurco L, Luquin E, Garcia-Granero M, Clavero P, San Martin-Uriz P, Vilas A, Mengual E, Hervas-Stubbs S, Aymerich MS. Abellanas MA, et al. J Neuroinflammation. 2019 Nov 22;16(1):233. doi: 10.1186/s12974-019-1628-8. J Neuroinflammation. 2019. PMID: 31757220 Free PMC article.
Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms.
Schilder BM, Navarro E, Raj T. Schilder BM, et al. Neurobiol Dis. 2022 Feb;163:105580. doi: 10.1016/j.nbd.2021.105580. Epub 2021 Dec 4. Neurobiol Dis. 2022. PMID: 34871738 Free PMC article. Review.
Immune system responses in Parkinson's disease: Early and dynamic.
Tansey MG, Romero-Ramos M. Tansey MG, et al. Eur J Neurosci. 2019 Feb;49(3):364-383. doi: 10.1111/ejn.14290. Epub 2018 Dec 10. Eur J Neurosci. 2019. PMID: 30474172 Free PMC article. Review.

Cytokine gene polymorphisms and Parkinson's disease: a meta-analysis - PubMed (original) (raw)