Macrophage-dependent, NK-cell-independent "natural" surveillance of tumors in syngeneic mice - PubMed (original) (raw)
Macrophage-dependent, NK-cell-independent "natural" surveillance of tumors in syngeneic mice
D A Chow et al. Int J Cancer. 1979.
Abstract
The present study, which was designed to further characterize the "natural" T-independent rejection of syngenetic tumours (Greenberg and Greene, 1976), has revealed the following points: (1) no detectable DBA/2 NK cell activity was demonstrated against the syngeneic tumour lines studied, and these tumours were indensitive to NK cells from high-activity strains; (2) in addition the tumour frequencies in old and young mice receiving small tumour inocula were identical, in contrast with the reported decline in NK cell activity with age, suggesting that the surveillance of small inocula of these tumours was NK-cell-independent; (3) injection of silica intraperitoneally enhanced the frequency of tumours in normal and immunodeficient AT x BM mice, suggesting that the rejection mechanism was macrophage-dependent; (4) the effects of silica injection were maximal if administered 3 days prior to tumour injection, indicating that the period of time in which the rejection mechanism must act was very limited; (5) silica markedly decreased the survival of AKR mice dying of spontaneous tumours, providing evidence that the effect of this agent was not limited to model systems but would influence the appearance of spontaneous tumours; (6) reticuloendothelial stimulants such as mycobacterium butyricum and proteose peptone decreased the tumour frequency of small tumour inocula, indicating that the effector mechanism can be stimulated; and (7) soluble tumour antigen enhanced the tumour frequency in normal and immunodeficient mice, suggesting that the specific receptor molecule of the surveillance mechanism was not thymus-dependent.
Similar articles
- Murine natural anti-tumor antibodies. II. The contribution of natural antibodies to tumor surveillance.
Chow DA, Wolosin LB, Greenberg AH. Chow DA, et al. Int J Cancer. 1981;27(4):459-69. doi: 10.1002/ijc.2910270407. Int J Cancer. 1981. PMID: 6792086 - Quantitative studies of natural immunity to solid tumours in rats. NK activity in animals with primary or transplanted spontaneous tumours.
Flannery GR, Brooks CG. Flannery GR, et al. Int J Cancer. 1981 Dec;28(6):747-55. doi: 10.1002/ijc.2910280614. Int J Cancer. 1981. PMID: 7333706 - Effect of poly I:C-activated peritoneal cells on the take of transplantable murine tumours.
Minárovits J, Karczag E, Földes I. Minárovits J, et al. Acta Microbiol Hung. 1987;34(3-4):197-205. Acta Microbiol Hung. 1987. PMID: 3129897 - The cytolytic and regulatory role of natural killer cells in experimental neoplasia.
Woodruff MF. Woodruff MF. Biochim Biophys Acta. 1986 Aug 5;865(1):43-57. doi: 10.1016/0304-419x(86)90012-0. Biochim Biophys Acta. 1986. PMID: 3524685 Review.
Cited by
- Detection of natural cytotoxicity in Syrian hamsters.
Rees RC, Hassan ZM, Potter CW. Rees RC, et al. Br J Cancer. 1980 Mar;41(3):485-8. doi: 10.1038/bjc.1980.75. Br J Cancer. 1980. PMID: 7387838 Free PMC article. No abstract available. - Alteration of the immune reactions by whole-body and local microwave hyperthermia in normal and tumour-bearing animals: review of own 1976-1980 experiments.
Janiak M, Szmigielski S. Janiak M, et al. Br J Cancer Suppl. 1982 Mar;5:122-6. Br J Cancer Suppl. 1982. PMID: 7039650 Free PMC article. No abstract available. - Tumor induction by simian virus 40 in mice is controlled by long-term persistence of the viral genome and the immune response of the host.
Abramczuk J, Pan S, Maul G, Knowles BB. Abramczuk J, et al. J Virol. 1984 Feb;49(2):540-8. doi: 10.1128/JVI.49.2.540-548.1984. J Virol. 1984. PMID: 6319753 Free PMC article. - Silica-induced malignant histiocytic lymphoma: incidence linked with strain of rat and type of silica.
Wagner MM, Wagner JC, Davies R, Griffiths DM. Wagner MM, et al. Br J Cancer. 1980 Jun;41(6):908-17. doi: 10.1038/bjc.1980.168. Br J Cancer. 1980. PMID: 6252921 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources