Mitochondrial morphology in mitophagy and macroautophagy - PubMed (original) (raw)
Review
. 2013 Jan;1833(1):205-12.
doi: 10.1016/j.bbamcr.2012.02.012. Epub 2012 Mar 1.
Affiliations
- PMID: 22406072
- DOI: 10.1016/j.bbamcr.2012.02.012
Free article
Review
Mitochondrial morphology in mitophagy and macroautophagy
Ligia C Gomes et al. Biochim Biophys Acta. 2013 Jan.
Free article
Abstract
Mitochondria are critical organelles in energy conversion, metabolism and amplification of signalling. They are however also major sources of reactive oxygen species and when dysfunctional they consume cytosolic ATP. Maintenance of a cohort of healthy mitochondria is therefore crucial for the overall cell fitness. Superfluous or damaged organelles are mainly degraded by mitophagy, a selective process of autophagy. In response to the triggers of mitophagy, mitochondria fragment: this morphological change accompanies the exposure of "eat-me" signals, resulting in the engulfment of the organelle by the autophagosomes. Conversely, during macroautophagy mitochondria fuse to be spared from degradation and to sustain ATP production in times of limited nutrient availability. Thus, mitochondrial shape defines different types of autophagy, highlighting the interplay between morphology of the organelle and complex cellular responses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.
Copyright © 2012 Elsevier B.V. All rights reserved.
Similar articles
- A Molecular Approach to Mitophagy and Mitochondrial Dynamics.
Yoo SM, Jung YK. Yoo SM, et al. Mol Cells. 2018 Jan 31;41(1):18-26. doi: 10.14348/molcells.2018.2277. Epub 2018 Jan 23. Mol Cells. 2018. PMID: 29370689 Free PMC article. Review. - Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction.
Deffieu M, Bhatia-Kiššová I, Salin B, Klionsky DJ, Pinson B, Manon S, Camougrand N. Deffieu M, et al. J Cell Sci. 2013 Jan 15;126(Pt 2):415-26. doi: 10.1242/jcs.103713. Epub 2012 Dec 10. J Cell Sci. 2013. PMID: 23230142 Free PMC article. - Regulation of autophagy by mitochondrial phospholipids in health and diseases.
Hsu P, Shi Y. Hsu P, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):114-129. doi: 10.1016/j.bbalip.2016.08.003. Epub 2016 Aug 5. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 27502688 Free PMC article. Review. - Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.
Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M, Sadoshima J. Ikeda Y, et al. J Mol Cell Cardiol. 2015 Jan;78:116-22. doi: 10.1016/j.yjmcc.2014.09.019. Epub 2014 Oct 7. J Mol Cell Cardiol. 2015. PMID: 25305175 Free PMC article. Review. - Mitochondrial dismissal in mammals, from protein degradation to mitophagy.
Campello S, Strappazzon F, Cecconi F. Campello S, et al. Biochim Biophys Acta. 2014 Apr;1837(4):451-60. doi: 10.1016/j.bbabio.2013.11.010. Epub 2013 Nov 22. Biochim Biophys Acta. 2014. PMID: 24275087 Review.
Cited by
- Ceramide induced mitophagy and tumor suppression.
Dany M, Ogretmen B. Dany M, et al. Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2834-45. doi: 10.1016/j.bbamcr.2014.12.039. Epub 2015 Jan 26. Biochim Biophys Acta. 2015. PMID: 25634657 Free PMC article. Review. - Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM. El-Sikhry HE, et al. PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016. PLoS One. 2016. PMID: 27494529 Free PMC article. - Mechanism and treatment of intracerebral hemorrhage focus on mitochondrial permeability transition pore.
Cong J, Li JY, Zou W. Cong J, et al. Front Mol Neurosci. 2024 Jul 31;17:1423132. doi: 10.3389/fnmol.2024.1423132. eCollection 2024. Front Mol Neurosci. 2024. PMID: 39156127 Free PMC article. Review. - Japanese Encephalitis Virus NS4A Protein Interacts with PTEN-Induced Kinase 1 (PINK1) and Promotes Mitophagy in Infected Cells.
Agarwal A, Alam MF, Basu B, Pattanayak S, Asthana S, Syed GH, Kalia M, Vrati S. Agarwal A, et al. Microbiol Spectr. 2022 Jun 29;10(3):e0083022. doi: 10.1128/spectrum.00830-22. Epub 2022 May 23. Microbiol Spectr. 2022. PMID: 35604158 Free PMC article. - Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons.
Cavallucci V, Bisicchia E, Cencioni MT, Ferri A, Latini L, Nobili A, Biamonte F, Nazio F, Fanelli F, Moreno S, Molinari M, Viscomi MT, D'Amelio M. Cavallucci V, et al. Cell Death Dis. 2014 Nov 27;5(11):e1545. doi: 10.1038/cddis.2014.511. Cell Death Dis. 2014. PMID: 25429622 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources