Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis - PubMed (original) (raw)
Comparative Study
. 1990 Nov;33(11):1665-73.
doi: 10.1002/art.1780331109.
Affiliations
- PMID: 2242063
- DOI: 10.1002/art.1780331109
Free article
Comparative Study
Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
B Richardson et al. Arthritis Rheum. 1990 Nov.
Free article
Abstract
Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.
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