Intermittent claudication, heart disease risk factors, and mortality. The Whitehall Study - PubMed (original) (raw)
Intermittent claudication, heart disease risk factors, and mortality. The Whitehall Study
G D Smith et al. Circulation. 1990 Dec.
Abstract
In the Whitehall study, 18,388 subjects aged 40-64 years completed a questionnaire on intermittent claudication. Of these subjects, 0.8% (147) and 1% (175) were deemed to have probable intermittent claudication and possible intermittent claudication, respectively. Within the 17-year follow-up period, 38% and 40% of the probable and possible cases, respectively, died. Compared with subjects without claudication, the probable cases suffered increased mortality rates due to coronary heart disease and cerebrovascular disease, but the mortality rate due to noncardiovascular causes was not increased. Possible cases demonstrated increased mortality rates due to cardiovascular and noncardiovascular causes. This difference in mortality pattern may be due to chance. Possible and probable cases still showed increased cardiovascular and all-cause mortality rates after adjusting for coronary risk factors (cardiac ischemia at baseline, systolic blood pressure, plasma cholesterol concentration, smoking behavior, employment grade, and degree of glucose intolerance). Intermittent claudication is independently related to increased mortality rates. It is not a rare condition, and simple questionnaires exist for its detection. The latter can be usefully incorporated in cardiovascular risk assessment and screening programs.
Comment in
- Peripheral arterial disease and subsequent cardiovascular mortality. A strong and consistent association.
Criqui MH. Criqui MH. Circulation. 1990 Dec;82(6):2246-7. doi: 10.1161/01.cir.82.6.2246. Circulation. 1990. PMID: 2242547 No abstract available.
Similar articles
- Prevalence of intermittent claudication and its effect on mortality.
Reunanen A, Takkunen H, Aromaa A. Reunanen A, et al. Acta Med Scand. 1982;211(4):249-56. doi: 10.1111/j.0954-6820.1982.tb01939.x. Acta Med Scand. 1982. PMID: 7102362 - Contribution of cardiovascular risk factors to coronary risk in patients with intermittent claudication in the PRIME Cohort Study of European men.
Tilloy E, Montaye M, Kee F, Bingham A, Arveiler D, Ruidavets JB, Evans A, Haas B, Ferrières J, Ducimetière P, Amouyel P, Dallongeville J. Tilloy E, et al. Atherosclerosis. 2009 Oct;206(2):563-8. doi: 10.1016/j.atherosclerosis.2009.03.025. Epub 2009 Apr 1. Atherosclerosis. 2009. PMID: 19403136 - Leg blood flow and long-term cardiovascular prognosis in men with typical and atypical intermittent claudication.
Ogren M, Hedblad B, Engström G, Janzon L. Ogren M, et al. Eur J Vasc Endovasc Surg. 2003 Sep;26(3):272-9. doi: 10.1053/ejvs.2002.2008. Eur J Vasc Endovasc Surg. 2003. PMID: 14509890 - Antiplatelet therapy to prevent cardiovascular events and mortality in patients with intermittent claudication.
Wong PF, Chong LY, Stansby G. Wong PF, et al. JAMA. 2013 Mar 6;309(9):926-7. doi: 10.1001/jama.2013.1490. JAMA. 2013. PMID: 23462789 Review. - Medical management of intermittent claudication.
Casey K, Tonnessen BH, Sternbergh WC 3rd, Money SR. Casey K, et al. Vasc Endovascular Surg. 2004 Sep-Oct;38(5):391-9. doi: 10.1177/153857440403800501. Vasc Endovascular Surg. 2004. PMID: 15490035 Review.
Cited by
- The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial.
Oyama J, Murohara T, Kitakaze M, Ishizu T, Sato Y, Kitagawa K, Kamiya H, Ajioka M, Ishihara M, Dai K, Nanasato M, Sata M, Maemura K, Tomiyama H, Higashi Y, Kaku K, Yamada H, Matsuhisa M, Yamashita K, Bando YK, Kashihara N, Ueda S, Inoue T, Tanaka A, Node K; PROLOGUE Study Investigators. Oyama J, et al. PLoS Med. 2016 Jun 28;13(6):e1002051. doi: 10.1371/journal.pmed.1002051. eCollection 2016 Jun. PLoS Med. 2016. PMID: 27351380 Free PMC article. Clinical Trial. - Leisure time physical activity and disease-specific mortality among men with chronic bronchitis: evidence from the Whitehall study.
Batty GD, Shipley MJ, Marmot MG, Smith GD. Batty GD, et al. Am J Public Health. 2003 May;93(5):817-21. doi: 10.2105/ajph.93.5.817. Am J Public Health. 2003. PMID: 12721150 Free PMC article. - Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study.
St-Pierre A, Cantin B, Lamarche B, Auger D, Després J, Dagenais GR. St-Pierre A, et al. Can J Cardiol. 2010 Jan;26(1):17-21. doi: 10.1016/s0828-282x(10)70328-7. Can J Cardiol. 2010. PMID: 20101352 Free PMC article. - Prevalence of peripheral artery disease and risk factors in the elderly: A community based cross-sectional study from northern Kerala, India.
Krishnan MN, Geevar Z, Mohanan PP, Venugopal K, Devika S. Krishnan MN, et al. Indian Heart J. 2018 Nov-Dec;70(6):808-815. doi: 10.1016/j.ihj.2017.11.001. Epub 2017 Nov 4. Indian Heart J. 2018. PMID: 30580849 Free PMC article. - The Incidence of Chronic Limb-Threatening Ischemia in the Midland Region of New Zealand over a 12-Year Period.
Hart O, Xue N, Davis-Havill B, Pottier M, Prakash M, Reimann SA, King J, Xu W, Khashram M. Hart O, et al. J Clin Med. 2022 Jun 9;11(12):3303. doi: 10.3390/jcm11123303. J Clin Med. 2022. PMID: 35743374 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical