The influence of S17 stromal cells and interleukin 7 on B cell development - PubMed (original) (raw)
The influence of S17 stromal cells and interleukin 7 on B cell development
A Cumano et al. Eur J Immunol. 1990 Oct.
Abstract
A clonal assay was used to study different stimuli involved in the progression of fetal liver B cell precursors to mature B lymphocytes. In this report we replaced fetal liver heterogenous feeder cells by a recombinant growth factor, interleukin 7 (IL 7), and a clonal stromal cell line, S17. Under those conditions we could clone 1 in 10 B220+ B cell precursors from fetal liver and the cells could differentiate to a mitogen-responsive, immunoglobulin-secreting stage. We found that IL 7 stimulates proliferation of B220+ precursors but is not sufficient to support maturation of those precursors to a stage of mitogen responsiveness. We show further that the cell line S17 does not produce IL 7 at functionally detectable level but provides support for B cell maturation. We conclude that this cell line supplies an exogenous stimulus required by B cell precursors to become mature lymphocytes. We describe therefore two stages in pre-B cell development: (a) IL 7-dependent proliferation and (b) S17-dependent maturation to mitogen reactivity. Further studies demonstrate that S17 has a profound effect on B cells by increasing the clonal efficiency of lipopolysaccharide-responsive cells to nearly 1:1 B cell in the spleen of adult C57BL/6 mice.
Similar articles
- Stromal cell-independent maturation of IL-7-responsive pro-B cells.
Ray RJ, Stoddart A, Pennycook JL, Huner HO, Furlonger C, Wu GE, Paige CJ. Ray RJ, et al. J Immunol. 1998 Jun 15;160(12):5886-97. J Immunol. 1998. PMID: 9637501 - [IL-7].
Yasunaga M, Nishikawa S. Yasunaga M, et al. Gan To Kagaku Ryoho. 1994 Sep;21(12):2077-83. Gan To Kagaku Ryoho. 1994. PMID: 8085864 Review. Japanese. - Regulatory cells and cytokines involved in primary B lymphocyte production.
Dorshkind K, Narayanan R, Landreth KS. Dorshkind K, et al. Adv Exp Med Biol. 1992;323:119-23. doi: 10.1007/978-1-4615-3396-2_15. Adv Exp Med Biol. 1992. PMID: 1283046 Review.
Cited by
- Expression of the ether-a-gò-gò-related gene 1 channel during B and T lymphocyte development: role in BCR and TCR signaling.
Sala C, Staderini M, Lottini T, Duranti C, Angelini G, Constantin G, Arcangeli A. Sala C, et al. Front Immunol. 2023 Sep 8;14:1111471. doi: 10.3389/fimmu.2023.1111471. eCollection 2023. Front Immunol. 2023. PMID: 37744334 Free PMC article. - Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection.
Müller U, Schaub GA, Mossmann H, Köhler G, Carsetti R, Hölscher C. Müller U, et al. Front Immunol. 2018 Dec 10;9:2794. doi: 10.3389/fimmu.2018.02794. eCollection 2018. Front Immunol. 2018. PMID: 30619242 Free PMC article. - TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells.
Baptista BJA, Granato A, Canto FB, Montalvão F, Tostes L, de Matos Guedes HL, Coutinho A, Bellio M, Vale AM, Nobrega A. Baptista BJA, et al. Front Immunol. 2018 Nov 28;9:2281. doi: 10.3389/fimmu.2018.02281. eCollection 2018. Front Immunol. 2018. PMID: 30546358 Free PMC article. - Effects of autologous stromal cells and cytokines on differentiation of equine bone marrow-derived progenitor cells.
Schwab UE, Tallmadge RL, Matychak MB, Felippe MJB. Schwab UE, et al. Am J Vet Res. 2017 Oct;78(10):1215-1228. doi: 10.2460/ajvr.78.10.1215. Am J Vet Res. 2017. PMID: 28945121 Free PMC article. - Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW. Fiala GJ, et al. J Exp Med. 2015 Sep 21;212(10):1693-708. doi: 10.1084/jem.20141271. Epub 2015 Aug 31. J Exp Med. 2015. PMID: 26324445 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials