Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex - PubMed (original) (raw)
. 2012 Mar 23;335(6075):1506-10.
doi: 10.1126/science.1217139.
Affiliations
- PMID: 22442486
- DOI: 10.1126/science.1217139
Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
Sarah Melzer et al. Science. 2012.
Abstract
The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
Similar articles
- Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1.
Aery Jones EA, Rao A, Zilberter M, Djukic B, Bant JS, Gillespie AK, Koutsodendris N, Nelson M, Yoon SY, Huang K, Yuan H, Gill TM, Huang Y, Frank LM. Aery Jones EA, et al. Cell Rep. 2021 Dec 28;37(13):110159. doi: 10.1016/j.celrep.2021.110159. Cell Rep. 2021. PMID: 34965435 Free PMC article. - Encoding and retrieval in a model of the hippocampal CA1 microcircuit.
Cutsuridis V, Cobb S, Graham BP. Cutsuridis V, et al. Hippocampus. 2010 Mar;20(3):423-46. doi: 10.1002/hipo.20661. Hippocampus. 2010. PMID: 19489002 - Excitatory Inputs Determine Phase-Locking Strength and Spike-Timing of CA1 Stratum Oriens/Alveus Parvalbumin and Somatostatin Interneurons during Intrinsically Generated Hippocampal Theta Rhythm.
Huh CY, Amilhon B, Ferguson KA, Manseau F, Torres-Platas SG, Peach JP, Scodras S, Mechawar N, Skinner FK, Williams S. Huh CY, et al. J Neurosci. 2016 Jun 22;36(25):6605-22. doi: 10.1523/JNEUROSCI.3951-13.2016. J Neurosci. 2016. PMID: 27335395 Free PMC article. - The long and short of GABAergic neurons.
Caputi A, Melzer S, Michael M, Monyer H. Caputi A, et al. Curr Opin Neurobiol. 2013 Apr;23(2):179-86. doi: 10.1016/j.conb.2013.01.021. Epub 2013 Feb 5. Curr Opin Neurobiol. 2013. PMID: 23394773 Review. - Neurogliaform cells and other interneurons of stratum lacunosum-moleculare gate entorhinal-hippocampal dialogue.
Capogna M. Capogna M. J Physiol. 2011 Apr 15;589(Pt 8):1875-83. doi: 10.1113/jphysiol.2010.201004. Epub 2010 Dec 6. J Physiol. 2011. PMID: 21135049 Free PMC article. Review.
Cited by
- Cortico-cortical transfer of socially derived information gates emotion recognition.
Dautan D, Monai A, Maltese F, Chang X, Molent C, Mauro D, Galbusera A, Vecchia D, Antonelli F, Benedetti A, Drago F, Leggio GM, Pagani M, Fellin T, Gozzi A, Schumann G, Managò F, Papaleo F. Dautan D, et al. Nat Neurosci. 2024 Jul;27(7):1318-1332. doi: 10.1038/s41593-024-01647-x. Epub 2024 May 20. Nat Neurosci. 2024. PMID: 38769153 - Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.
Takács V, Bardóczi Z, Orosz Á, Major A, Tar L, Berki P, Papp P, Mayer MI, Sebők H, Zsolt L, Sos KE, Káli S, Freund TF, Nyiri G. Takács V, et al. PLoS Biol. 2024 Mar 12;22(3):e3002539. doi: 10.1371/journal.pbio.3002539. eCollection 2024 Mar. PLoS Biol. 2024. PMID: 38470935 Free PMC article. - Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease.
Spoleti E, La Barbera L, Cauzzi E, De Paolis ML, Saba L, Marino R, Sciamanna G, Di Lazzaro V, Keller F, Nobili A, Krashia P, D'Amelio M. Spoleti E, et al. Mol Psychiatry. 2024 May;29(5):1265-1280. doi: 10.1038/s41380-024-02408-9. Epub 2024 Jan 16. Mol Psychiatry. 2024. PMID: 38228889 Free PMC article. - Parvalbumin-positive neurons in the medial vestibular nucleus contribute to vestibular compensation through commissural inhibition.
Zhang Y, Chu G, Leng Y, Lin X, Zhou H, Lu Y, Liu B. Zhang Y, et al. Front Cell Neurosci. 2023 Nov 8;17:1260243. doi: 10.3389/fncel.2023.1260243. eCollection 2023. Front Cell Neurosci. 2023. PMID: 38026699 Free PMC article. - Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability.
Pracucci E, Graham RT, Alberio L, Nardi G, Cozzolino O, Pillai V, Pasquini G, Saieva L, Walsh D, Landi S, Zhang J, Trevelyan AJ, Ratto GM. Pracucci E, et al. Nat Commun. 2023 Nov 4;14(1):7108. doi: 10.1038/s41467-023-42711-7. Nat Commun. 2023. PMID: 37925453 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases