Interferons as biomarkers and effectors: lessons learned from animal models - PubMed (original) (raw)
Review
Interferons as biomarkers and effectors: lessons learned from animal models
Cassandra M Berry et al. Biomark Med. 2012 Apr.
Abstract
Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease outcome. Animal models allow investigations into disease pathogenesis and gene knockout models have proved cause and effect relationships of molecules related to the IFN response. Sets of IFN subtypes and their ISG products provide immunological signature patterns for different viral and other diseases. In this article, we give an overview of IFNs in several virus infection models and autoimmune diseases of medical relevance. Lessons learned from animal models inform us of IFN system parameters as indicators of disease outcome and whether clinical research is warranted. Moreover, validated IFN biomarkers for prognosis enhance our understanding of therapeutic and vaccine development.
Similar articles
- Interferons as pathogenic effectors in autoimmunity.
Baccala R, Kono DH, Theofilopoulos AN. Baccala R, et al. Immunol Rev. 2005 Apr;204:9-26. doi: 10.1111/j.0105-2896.2005.00252.x. Immunol Rev. 2005. PMID: 15790347 Review. - Interferon-Stimulated Genes: What Do They All Do?
Schoggins JW. Schoggins JW. Annu Rev Virol. 2019 Sep 29;6(1):567-584. doi: 10.1146/annurev-virology-092818-015756. Epub 2019 Jul 5. Annu Rev Virol. 2019. PMID: 31283436 Review. - Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.
Zhang SY, Boisson-Dupuis S, Chapgier A, Yang K, Bustamante J, Puel A, Picard C, Abel L, Jouanguy E, Casanova JL. Zhang SY, et al. Immunol Rev. 2008 Dec;226:29-40. doi: 10.1111/j.1600-065X.2008.00698.x. Immunol Rev. 2008. PMID: 19161414 Review. - Evolutionary genetic dissection of human interferons.
Manry J, Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci L. Manry J, et al. J Exp Med. 2011 Dec 19;208(13):2747-59. doi: 10.1084/jem.20111680. Epub 2011 Dec 12. J Exp Med. 2011. PMID: 22162829 Free PMC article. Clinical Trial. - Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature.
Sugrue JA, Bourke NM, O'Farrelly C. Sugrue JA, et al. Front Immunol. 2021 Nov 30;12:757249. doi: 10.3389/fimmu.2021.757249. eCollection 2021. Front Immunol. 2021. PMID: 34917078 Free PMC article. Review.
Cited by
- Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types.
Tomasello E, Pollet E, Vu Manh TP, Uzé G, Dalod M. Tomasello E, et al. Front Immunol. 2014 Oct 30;5:526. doi: 10.3389/fimmu.2014.00526. eCollection 2014. Front Immunol. 2014. PMID: 25400632 Free PMC article. Review. - Multifaceted activities of type I interferon are revealed by a receptor antagonist.
Levin D, Schneider WM, Hoffmann HH, Yarden G, Busetto AG, Manor O, Sharma N, Rice CM, Schreiber G. Levin D, et al. Sci Signal. 2014 May 27;7(327):ra50. doi: 10.1126/scisignal.2004998. Sci Signal. 2014. PMID: 24866020 Free PMC article. - Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
Rinaldi C, Penhale WJ, Stumbles PA, Tay G, Berry CM. Rinaldi C, et al. PLoS One. 2014 Feb 28;9(2):e89674. doi: 10.1371/journal.pone.0089674. eCollection 2014. PLoS One. 2014. PMID: 24586955 Free PMC article. - Biology of mucosally transmitted sexual infection-translating the basic science into novel HIV intervention: a workshop summary.
Purcell D, Cunningham A, Turville S, Tachedjian G, Landay A. Purcell D, et al. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1389-96. doi: 10.1089/AID.2012.0276. Epub 2012 Oct 10. AIDS Res Hum Retroviruses. 2012. PMID: 22966898 Free PMC article. - Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.
Piehler J, Thomas C, Garcia KC, Schreiber G. Piehler J, et al. Immunol Rev. 2012 Nov;250(1):317-34. doi: 10.1111/imr.12001. Immunol Rev. 2012. PMID: 23046138 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical