MiR-125 in normal and malignant hematopoiesis - PubMed (original) (raw)

Review

doi: 10.1038/leu.2012.90. Epub 2012 Mar 29.

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• PMID: 22456625
• DOI: 10.1038/leu.2012.90

Review

MiR-125 in normal and malignant hematopoiesis

L Shaham et al. Leukemia. 2012 Sep.

Abstract

MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation.

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