Hierarchical genetic organization of human cortical surface area - PubMed (original) (raw)

. 2012 Mar 30;335(6076):1634-6.

doi: 10.1126/science.1215330.

E D Gutierrez, Wes Thompson, Matthew S Panizzon, Terry L Jernigan, Lisa T Eyler, Christine Fennema-Notestine, Amy J Jak, Michael C Neale, Carol E Franz, Michael J Lyons, Michael D Grant, Bruce Fischl, Larry J Seidman, Ming T Tsuang, William S Kremen, Anders M Dale

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Hierarchical genetic organization of human cortical surface area

Chi-Hua Chen et al. Science. 2012.

Abstract

Surface area of the cerebral cortex is a highly heritable trait, yet little is known about genetic influences on regional cortical differentiation in humans. Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, we parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data. Boundaries of the genetic divisions corresponded largely to meaningful structural and functional regions; however, the divisions represented previously undescribed phenotypes different from conventional (non-genetically based) parcellation systems. The genetic organization of cortical area was hierarchical, modular, and predominantly bilaterally symmetric across hemispheres. We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns.

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Figures

Fig. 1

Fig. 1

Genetic clustering map for 12-cluster solution. 1, motor-premotor cortex; 2, dorsolateral prefrontal cortex; 3, dorsomedial frontal cortex; 4, orbitofrontal cortex; 5, pars opercularis and subcentral region; 6, superior temporal cortex; 7, posterolateral temporal cortex; 8, anteromedial temporal cortex; 9, inferior parietal cortex; 10, superior parietal cortex; 11, precuneus; and 12, occipital cortex. Views shown from left to right are, respectively, superior, left hemisphere lateral, right hemisphere lateral, left hemisphere medial, right hemisphere medial, and inferior.

Fig. 2

Fig. 2

Genetic similarity matrix and dendrogram. The color scale represents the weighted mean genetic correlations within and between clusters. Negative genetic correlations indicate that the genes that cause areal expansion in anterior regions also cause relative areal contraction in posterior regions and vice versa (8).

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References

    1. Bergquist H, Kallen B. Acta Anat (Basel) 1953;18:65. - PubMed
    1. Fraser S, Keynes R, Lumsden A. Nature. 1990;344:431. - PubMed
    1. Wilkinson DG, Bhatt S, Cook M, Boncinelli E, Krumlauf R. Nature. 1989;341:405. - PubMed
    1. Puelles L, Rubenstein JL. Trends Neurosci. 2003;26:469. - PubMed
    1. Bishop KM, Goudreau G, O’Leary DD. Science. 2000;288:344. - PubMed

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