Oxidative stress increases continuously with BMI and age with unfavourable profiles in males - PubMed (original) (raw)
Oxidative stress increases continuously with BMI and age with unfavourable profiles in males
Willibald Wonisch et al. Aging Male. 2012 Sep.
Free article
Abstract
Oxidative stress is a risk factor for chronic diseases and was previously shown to be independently associated with obesity. The authors investigated the relationship between body mass index (BMI), age and oxidative stress on 2190 subjects undergoing a health care examination. Total antioxidant status (TAS), total peroxides (TOC) and autoantibodies against oxidized LDL (oLAb) were used as oxidative stress biomarkers in addition to serum lipoproteins, bilirubin and uric acid. Gender-specific differences were observed for age, BMI, serum concentrations of bilirubin, low-density lipoprotein (LDL), uric acid and TAS, all of which were higher in males (p < 0.001), while high-density lipoprotein (HDL), HDL/LDL ratio and TOC were higher in females (p < 0.001). Total cholesterol (p < 0.05) and LDL were increased (p < 0.05), while HDL was decreased (p < 0.05) in overweight and obese subjects. This was accompanied by increased uric acid and TAS concentrations. Lowest oLAb titers were detected in obese subjects. In extremely obese subjects, increased TOC and decreased TAS were observed in spite of high uric acid levels. These results demonstrate that oxidative stress increases with increasing BMI and age, as a sequel to an impaired antioxidant status, the consumption of oLAbs, an increase of peroxides and uric acid and a disadvantaged lipid profile.
Similar articles
- Total bilirubin in young men and women: association with risk markers for cardiovascular diseases.
Stojanov M, Stefanovic A, Dzingalasevic G, Ivanisevic J, Miljkovic M, Mandic-Radic S, Prostran M. Stojanov M, et al. Clin Biochem. 2013 Oct;46(15):1516-9. doi: 10.1016/j.clinbiochem.2013.06.020. Epub 2013 Jul 2. Clin Biochem. 2013. PMID: 23827733 - Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men.
Karaouzene N, Merzouk H, Aribi M, Merzouk SA, Berrouiguet AY, Tessier C, Narce M. Karaouzene N, et al. Nutr Metab Cardiovasc Dis. 2011 Oct;21(10):792-9. doi: 10.1016/j.numecd.2010.02.007. Epub 2010 Jun 2. Nutr Metab Cardiovasc Dis. 2011. PMID: 20554180 - [Body fat distribution: its characteristics and relationship to cardiovascular risk factors in obese Chinese].
Ran XW, Li XS, Tong NW, Li QF, Tang BD, Li XJ. Ran XW, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):699-703. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004. PMID: 15460424 Chinese. - Prevalence of metabolic syndrome among Filipino adults aged 20 years and over.
Tanchoco CC, Cruz AJ, Duante CA, Litonjua AD. Tanchoco CC, et al. Asia Pac J Clin Nutr. 2003;12(3):271-6. Asia Pac J Clin Nutr. 2003. PMID: 14505989 - Gender-dependent impacts of body mass index and moderate alcohol consumption on serum uric acid--an index of oxidant stress status?
Alatalo PI, Koivisto HM, Hietala JP, Bloigu RS, Niemelä OJ. Alatalo PI, et al. Free Radic Biol Med. 2009 Apr 15;46(8):1233-8. doi: 10.1016/j.freeradbiomed.2009.02.002. Epub 2009 Feb 12. Free Radic Biol Med. 2009. PMID: 19439211
Cited by
- Nutrition and Chronic Wounds.
Molnar JA, Underdown MJ, Clark WA. Molnar JA, et al. Adv Wound Care (New Rochelle). 2014 Nov 1;3(11):663-681. doi: 10.1089/wound.2014.0530. Adv Wound Care (New Rochelle). 2014. PMID: 25371850 Free PMC article. Review. - Pancreas-Liver-Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases.
Moroni-González D, Sarmiento-Ortega VE, Diaz A, Brambila E, Treviño S. Moroni-González D, et al. Toxics. 2023 Feb 26;11(3):223. doi: 10.3390/toxics11030223. Toxics. 2023. PMID: 36976988 Free PMC article. Review. - Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue.
Sakurai T, Ogasawara J, Shirato K, Izawa T, Oh-Ishi S, Ishibashi Y, Radák Z, Ohno H, Kizaki T. Sakurai T, et al. Oxid Med Cell Longev. 2017;2017:9410954. doi: 10.1155/2017/9410954. Epub 2017 Jan 12. Oxid Med Cell Longev. 2017. PMID: 28168013 Free PMC article. Review. - Effects of a Novel Magnesium Complex on Metabolic and Cognitive Functions and the Expression of Synapse-Associated Proteins in Rats Fed a High-Fat Diet.
Orhan C, Tuzcu M, Deeh Defo PB, Sahin N, Ojalvo SP, Sylla S, Komorowski JR, Sahin K. Orhan C, et al. Biol Trace Elem Res. 2022 Jan;200(1):247-260. doi: 10.1007/s12011-021-02619-z. Epub 2021 Feb 16. Biol Trace Elem Res. 2022. PMID: 33591492 - Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic of Metabolic Syndrome and Premature Coronary Heart Disease-Family Study.
Paavola T, Bergmann U, Kuusisto S, Kakko S, Savolainen MJ, Salonurmi T. Paavola T, et al. Int J Mol Sci. 2021 May 6;22(9):4908. doi: 10.3390/ijms22094908. Int J Mol Sci. 2021. PMID: 34066314 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical