The stem cell niche in regenerative medicine - PubMed (original) (raw)

Review

. 2012 Apr 6;10(4):362-9.

doi: 10.1016/j.stem.2012.02.018.

Affiliations

• PMID: 22482502
• DOI: 10.1016/j.stem.2012.02.018

Free article

Review

The stem cell niche in regenerative medicine

Amy J Wagers. Cell Stem Cell. 2012.

Free article

Abstract

Stem cells are fundamental units for achieving regenerative therapies, which leads naturally to a theoretical and experimental focus on these cells for therapeutic screening and intervention. A growing body of data in many tissue systems indicates that stem cell function is critically influenced by extrinsic signals derived from the microenvironment, or "niche." In this vein, the stem cell niche represents a significant, and largely untapped, entry point for therapeutic modulation of stem cell behavior. This Perspective will discuss how the niche influences stem cells in homeostasis, in the progression of degenerative and malignant diseases, and in therapeutic strategies for tissue repair.

Copyright © 2012 Elsevier Inc. All rights reserved.

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