A stem cell-based approach to cartilage repair - PubMed (original) (raw)

. 2012 May 11;336(6082):717-21.

doi: 10.1126/science.1215157. Epub 2012 Apr 5.

Affiliations

• PMID: 22491093
• DOI: 10.1126/science.1215157

A stem cell-based approach to cartilage repair

Kristen Johnson et al. Science. 2012.

Abstract

Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that promote the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes may stimulate the repair of damaged cartilage. Using an image-based high-throughput screen, we identified the small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. This work provides new insights into the control of chondrogenesis that may ultimately lead to a stem cell-based therapy for osteoarthritis.

PubMed Disclaimer

Comment in

• Therapy. Tissue engineering: harnessing stem cells in cartilage repair.
  Ray K. Ray K. Nat Rev Rheumatol. 2012 Jun;8(6):308. doi: 10.1038/nrrheum.2012.62. Nat Rev Rheumatol. 2012. PMID: 22826829 No abstract available.
• Kartogenin: a game-changer in regenerative medicine.
  Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Hayek A, et al. Regen Med. 2012 Jul;7(4):475. Regen Med. 2012. PMID: 22993885 No abstract available.

Similar articles

• Replenishing cartilage from endogenous stem cells.
  Marini JC, Forlino A. Marini JC, et al. N Engl J Med. 2012 Jun 28;366(26):2522-4. doi: 10.1056/NEJMcibr1204283. N Engl J Med. 2012. PMID: 22738103 Free PMC article. No abstract available.
• Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration.
  Kang ML, Ko JY, Kim JE, Im GI. Kang ML, et al. Biomaterials. 2014 Dec;35(37):9984-9994. doi: 10.1016/j.biomaterials.2014.08.042. Epub 2014 Sep 17. Biomaterials. 2014. PMID: 25241157
• Kartogenin inhibits pain behavior, chondrocyte inflammation, and attenuates osteoarthritis progression in mice through induction of IL-10.
  Kwon JY, Lee SH, Na HS, Jung K, Choi J, Cho KH, Lee CY, Kim SJ, Park SH, Shin DY, Cho ML. Kwon JY, et al. Sci Rep. 2018 Sep 14;8(1):13832. doi: 10.1038/s41598-018-32206-7. Sci Rep. 2018. PMID: 30218055 Free PMC article.
• Recent advances in kartogenin for cartilage regeneration.
  Cai G, Liu W, He Y, Huang J, Duan L, Xiong J, Liu L, Wang D. Cai G, et al. J Drug Target. 2019 Jan;27(1):28-32. doi: 10.1080/1061186X.2018.1464011. Epub 2018 May 30. J Drug Target. 2019. PMID: 29772932 Review.
• The use of mesenchymal stem cells for chondrogenesis.
  Pelttari K, Steck E, Richter W. Pelttari K, et al. Injury. 2008 Apr;39 Suppl 1:S58-65. doi: 10.1016/j.injury.2008.01.038. Injury. 2008. PMID: 18313473 Review.

Cited by

• Magnetic nanocarriers as a therapeutic drug delivery strategy for promoting pain-related motor functions in a rat model of cartilage transplantation.
  Zhang X, Yang J, Cheng B, Zhao S, Li Y, Kang H, Chen S. Zhang X, et al. J Mater Sci Mater Med. 2021 Mar 31;32(4):37. doi: 10.1007/s10856-021-06508-8. J Mater Sci Mater Med. 2021. PMID: 33787997 Free PMC article.
• Non-surgical treatments for the management of early osteoarthritis.
  Filardo G, Kon E, Longo UG, Madry H, Marchettini P, Marmotti A, Van Assche D, Zanon G, Peretti GM. Filardo G, et al. Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6):1775-85. doi: 10.1007/s00167-016-4089-y. Epub 2016 Apr 4. Knee Surg Sports Traumatol Arthrosc. 2016. PMID: 27043347 Review.
• Integrin signalling in joint development, homeostasis and osteoarthritis.
  Miao MZ, Lee JS, Yamada KM, Loeser RF. Miao MZ, et al. Nat Rev Rheumatol. 2024 Aug;20(8):492-509. doi: 10.1038/s41584-024-01130-8. Epub 2024 Jul 16. Nat Rev Rheumatol. 2024. PMID: 39014254 Review.
• Regulation of Skeletal Development and Maintenance by Runx2 and Sp7.
  Komori T. Komori T. Int J Mol Sci. 2024 Sep 20;25(18):10102. doi: 10.3390/ijms251810102. Int J Mol Sci. 2024. PMID: 39337587 Free PMC article. Review.
• Functional Nanomaterials for the Treatment of Osteoarthritis.
  Yi X, Leng P, Wang S, Liu L, Xie B. Yi X, et al. Int J Nanomedicine. 2024 Jul 4;19:6731-6756. doi: 10.2147/IJN.S465243. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38979531 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • NIAID Data Ecosystem - Find datasets on Infectious and Immune-mediated Diseases