A complex Polycomb issue: the two faces of EZH2 in cancer - PubMed (original) (raw)

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A complex Polycomb issue: the two faces of EZH2 in cancer

Hanno Hock. Genes Dev. 2012.

Abstract

In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651-656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.

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• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.
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